Background and Objective: Pleomorphic xanthoastrocytoma
(PXA) is a rare primary WHO Grade II astrocytic tumor comprising of 5% in five tumors.
The morphologic features, in consideration of immunophenotype, are diagnostic of anaplastic pleomorphic xanthoastrocytoma
(WHO grade III).
Interestingly, approximately half of epithelioid glioblastomas harbour the BRAF V600E mutation, thus exhibiting morphologic and molecular overlap with pleomorphic xanthoastrocytoma
In these locations, schwannomas can resemble other more common intra-axial cystic neoplasms including pilocytic astrocytoma, pleomorphic xanthoastrocytoma
, meningioma if near a centrally located nerve root [9, 10, 13, 14], or less commonly a high-grade glial tumor .
A magnetic resonance imaging scan was subsequently done, and the report suggested the presence of a large, left frontal lobe, multicystic inhomogenous tumour with characteristics consistent with a ganglioglioma or pleomorphic xanthoastrocytoma
Keywords: Pleomorphic xanthoastrocytoma
, Mural nodule, Supratentorial, GFAP.
Tumor histology of pediatric patients with brain tumors (n=136) Tumor N Pilocytic astrocytoma (WHO grade I) 42 Medulloblastoma 12 Ependymoma (WHO grades I , II, III) 11 Astrocytoma (WHO grade II) 11 Craniopharyngioma 11 Astrocytoma (WHO (grades III & IV) 6 Choroid plexus papilloma (WHO grade I) 5 Germinoma 5 PNET 5 Dermoid cyst 4 SEGA (WHO grade I) 4 Meningioma 3 Ganglioglioma (WHO grade I) 2 Metastatic 2 Oligodendroglioma (WHO grade II) 3 Choroid plexus carcinoma (WHO grade III) 1 Epidermoid cyst 1 Hemangiopericytoma 1 Pilomyxoid astrocytoma 1 Pineocytoma (WHO grade II) 1 Pleomorphic xanthoastrocytoma
2 Rathke's cleft cyst 1 Schwannoma (WHO grade I) 1 Pituitary adenoma 1 Table 3.
We present a case of melanotic pleomorphic xanthoastrocytoma
and discuss its histogenesis.
(PXA) and ganglioglioma (GG) are typically superficial, supratentorial, solid, and cystic lesions with a predilection for the temporal lobes of young patients who present with a protracted history of seizures.