pleomorphic xanthoastrocytoma

ple·o·mor·phic xan·tho·as·tro·cy·to·ma

a rare variant of astrocytoma usually presenting early in life with seizures. The tumor is superficially located and composed of pleomorphic glial cells, lipidized astrocytes, and perivascular lymphocytes.
Synonym(s): xanthoastrocytoma
Farlex Partner Medical Dictionary © Farlex 2012

pleomorphic xanthoastrocytoma

(zan″thō-as″trŏ-sī-tō′mă) [ xantho- + astrocytoma],

PXA

A rare, relatively slow-growing astrocytoma composed of cells of many sizes and shapes. The tumor is usually diagnosed in adolescents and young adults. Microscopic specimens often reveal fatty cells, fibrillar cells, and involvement of the leptomeninges of the brain.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Background and Objective: Pleomorphic xanthoastrocytoma (PXA) is a rare primary WHO Grade II astrocytic tumor comprising of 5% in five tumors.
The morphologic features, in consideration of immunophenotype, are diagnostic of anaplastic pleomorphic xanthoastrocytoma (WHO grade III).
Interestingly, approximately half of epithelioid glioblastomas harbour the BRAF V600E mutation, thus exhibiting morphologic and molecular overlap with pleomorphic xanthoastrocytoma [1-5].
In these locations, schwannomas can resemble other more common intra-axial cystic neoplasms including pilocytic astrocytoma, pleomorphic xanthoastrocytoma [7], meningioma if near a centrally located nerve root [9, 10, 13, 14], or less commonly a high-grade glial tumor [11].
A magnetic resonance imaging scan was subsequently done, and the report suggested the presence of a large, left frontal lobe, multicystic inhomogenous tumour with characteristics consistent with a ganglioglioma or pleomorphic xanthoastrocytoma.
Keywords: Pleomorphic xanthoastrocytoma, Mural nodule, Supratentorial, GFAP.
Tumor histology of pediatric patients with brain tumors (n=136) Tumor N Pilocytic astrocytoma (WHO grade I) 42 Medulloblastoma 12 Ependymoma (WHO grades I , II, III) 11 Astrocytoma (WHO grade II) 11 Craniopharyngioma 11 Astrocytoma (WHO (grades III & IV) 6 Choroid plexus papilloma (WHO grade I) 5 Germinoma 5 PNET 5 Dermoid cyst 4 SEGA (WHO grade I) 4 Meningioma 3 Ganglioglioma (WHO grade I) 2 Metastatic 2 Oligodendroglioma (WHO grade II) 3 Choroid plexus carcinoma (WHO grade III) 1 Epidermoid cyst 1 Hemangiopericytoma 1 Pilomyxoid astrocytoma 1 Pineocytoma (WHO grade II) 1 Pleomorphic xanthoastrocytoma 2 Rathke's cleft cyst 1 Schwannoma (WHO grade I) 1 Pituitary adenoma 1 Table 3.
We present a case of melanotic pleomorphic xanthoastrocytoma and discuss its histogenesis.
Pleomorphic xanthoastrocytoma (PXA) and ganglioglioma (GG) are typically superficial, supratentorial, solid, and cystic lesions with a predilection for the temporal lobes of young patients who present with a protracted history of seizures.