The spindle cell proliferation can have banal morphology, or it can be pleomorphic
, and it may be mixed with an epithelial component, which may be benign or malignant.
12) The pleomorphic
variant of mantle cell lymphoma is composed of numerous large cells with irregular nuclear contours and prominent nucleoli, as was seen in the spleen.
Multiple clusters of pleomorphic
or amorphous calcifications may be the presenting features of micropapillary DCIS.
TABLE 1 Distribution and Frequency of Parotid Tumors by Pathology and Patient Sex Type of Tumor Male Female Benign Pleomorphic
adenoma 2 16 Warthin's tumor 6 2 Inflammatory 1 5 Monomorphic adenoma 3 Lipoma 1 Subtotal 13 23 Malignant tumors Squamous cell carcinoma 5 1 Adenocarcinoma 3 2 Lymphoma 1 1 Merkle cell carcinoma 1 Basaloid neoplasm 1 Subtotal 11 4 Total 24 27 Type of Tumor Total Benign Pleomorphic
adenoma 18 Warthin's tumor 8 Inflammatory 6 Monomorphic adenoma 3 Lipoma 1 Subtotal 36 Malignant tumors Squamous cell carcinoma 6 Adenocarcinoma 5 Lymphoma 2 Merkle cell carcinoma 1 Basaloid neoplasm 1 Subtotal 15 Total 51 TABLE 2 Pathology as Function of Sex Sex Nonmalignant Malignant Total Female 23 4 27 Male 13 11 24 Total 36 15 51 DF Value Probability Chi-square 1 5.
The pathology report was consistent with a pleomorphic
Minor criteria include glands with (1) right-angle branching or (2) smooth, rounded outlines; and (3) 2 cell populations with an outer perimeter cell group composed of tall, pleomorphic
, and mitotically active cells that stain poorly for prostate-specific antigen (PSA), and a central group that is cuboidal, monomorphic, and quiescent, with abundant cytoplasm containing abundant PSA and occasional extracellular mucin.
However, the appearance of a "standard" epithelioid cell is variable because some epithelioid cells can have small nuclei and small nucleoli with limited amounts of cytoplasm, while other epithelioid cells can have large eccentrically-placed vesicular pleomorphic
nuclei and prominent macronucleoli and abundant cytoplasm.
It is an interesting condition as the lesion is often mistaken for a malignancy clinically and for a pleomorphic
The malignant portion of the tumor was therefore interpreted as a pleomorphic
(spindle and squamous cell) carcinoma.
13) Overexpression of MDM2 mRNA has been reported in most salivary gland tumor cell lines (pleomorphic
adenoma; epithelial-myoepithelial carcinoma; carcinoma ex pleomorphic
adenoma; adenoid cystic carcinoma; adenocarcinoma, not otherwise specified).
adenoma is the most common benign tumor of the salivary glands, most typically arising from the parotid gland.
adenoma (PA) is the most common neoplasm of salivary gland origin.