pleiotropy


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Related to pleiotropy: pleiotropism, epistasis

pleiotropy

 [pli-ot´rŏ-pe]
the production by a single gene of multiple phenotypic effects. The term is often used to refer to a single gene defect that is expressed as problems in multiple systems of the body, such as in osteogenesis imperfecta, where the gene causes defects in several different systems that contain collagen.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

plei·ot·ro·py

, pleiotropia (plī-ot'rō-pē, plī-ō-trō'pē-ă),
Production by a single mutant gene of apparently unrelated multiple effects at the clinical or phenotypic level.
[pleio- + G. tropos, turning]
Farlex Partner Medical Dictionary © Farlex 2012

pleiotropy

(plī-ŏt′rə-pē) also

pleiotropism

(-pĭz′əm)
n. Biology
The production of diverse effects, especially the production by a single gene of several distinct and seemingly unrelated phenotypic effects.

plei′o·tro′pic (plī′ə-trō′pĭk, -trŏp′ĭk) adj.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

plei·ot·ro·py

, pleiotropia (plī-ot'rŏ-pē, -ō-trō'pē-ă)
Production by a single mutant gene of apparently unrelated multiple effects at the clinical or phenotypic level.
[pleio- + G. tropos, turning]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
These results suggest that most of the correlated response of PSRI to selection for NDF was due to pleiotropic effects of loci, or to very tight linkages between loci controlling the two traits, a phenomenon that cannot be distinguished from pleiotropy without very large populations and/or several cycles of recombination.
In addition, it is necessary to determine if coincident QTL are the result of tight linkage or pleiotropy. In the case of tight linkage, screening large numbers of recombinants may be necessary to break up the linkage.
The characteristics of the parental pairs suggest that at least partly the associated responses to selection were determined by pleiotropy, with genes for high ABA having a negative effect on the agronomic performance.
Fine-scale mapping of QTL and ultimate identification of the genes and allelic substitutions involved is necessary to determine the relative importance of pleiotropy versus linkage in the similarities of the LOD profiles.
Each of these can be understood through examining the process of meiosis Mendelian A method of using measured variation in genes of known randomisation function to examine the causal effect of a modifiable exposure on disease in observational studies Penetrance The probability of a gene or trait being expressed Phenotype The physical expression, or characteristics, of that trait due to a specific genotype Pleiotropy The ability of a single gene to influence multiple phenotypic traits Table 2.
A distinctive feature of the regulatory peptides is pleiotropy, or the ability to affect several different physiological functions.
For instance, three independent studies showed that serum uric acid was associated with subclinical atherosclerosis (1,4,19), but a Mendelian randomization analysis showed that the causal effect of uric acid could be inflated by hidden pleiotropy (6).
Collectively, these multifactorial effects raise the possibility of gene pleiotropy influencing the outcome measure, which could invalidate the Mendelian randomization (8).
On the other hand, NMS may manifest as symptoms of aging-associated neurodegenerative disease through an antagonistic pleiotropy mechanism in the parental brains.
Smoller, "Pleiotropy in complex traits: challenges and strategies," Nature Reviews Genetics, vol.
Third, genetic analysis of TFs in the nonspecific world will uncover differential pleiotropy. Differential pleiotropy is observed for the HD containing Drosophila, Human and yeast TFs: Ultrabithorax, Fushi tarazu, Sex combs reduced, Antennapedia, HOXA7, HOXB3, and Pho2p; therefore, in order to make a more general statement, observation of differential pleiotropy needs to be extended to other TF families.