A combined linkage and regional association mapping validation and fine mapping of two major pleiotropic
QTLs for seed weight and silique length in rapeseed (Brassica napus L.).
Both oxidative stress and endothelial cell dysfunction contribute to the development of atherosclerosis. Ox-LDL is the key factor to induce oxidative stress and endothelial apoptosis in EC, which is essential for the initiation and progression of atherosclerosis., Our previous study has shown that ox-LDL induced apoptosis in vascular endothelial cells largely through the PERK/eIF2a/CHOP ER stress pathway. Statins are effective cholesterol-lowering drugs that exert pleiotropic
effects including inhibitory effects on inflammation, oxidative stress, and tissue repair. In the present study, we provided the evidence that statins could inhibit ox-LDL-induced ER stress and apoptosis in vascular endothelial cells.
However, in this experimental study, we aimed to evaluate the pleiotropic
effects of statin independent from its lipid-lowering effects.
The KIT-ligand (steel factor) and its receptor c-KIT/W: pleiotropic
roles in gametogenesis and melanogenesis.
Investigation of the vascular and Pleiotropic
effects of atorvastatin and pioglitazone in a population at high cardiovascular risk.
Beneficial cardiovascular pleiotropic
effects of statins.
Statins are commonly prescribed lipid-lowering agents but have multiple secondary effects [6, 23, 24], and the degree of these pleiotropic
effects appears to vary between statins .
Thus, metformin appears to have very important effects on the human gut microbiome that contribute to its pleiotropic
beneficial antidiabetic effects, but an individual's tolerance to metformin can also be influenced by their inherent gut microbiome.
Cell-based therapy is distinguished from small molecule strategies by the pleiotropic
mechanisms of action that have been determined in preclinical data and an excellent safety profile in early clinical trials.
Few studies have suggested the pleiotropic
effect of warfarin.
This study, using Mendelian randomization and sophisticated analyses to adjust for pleiotropic
effects, advances our knowledge; however, it seems that other approaches are required to further evaluate the causal relevance of each of these lipid fractions in association with type 2 diabetes.
Other topics include the transcriptional control of dendritic cell development, the genomics of immune diseases and new therapies, chemokines and chemokine receptors in lymphoid tissue dynamics, the innate lymphoid cell precursor, retinoic acid and retinoic acid receptors as pleiotropic
modulators of the immune system, auto-antigens as partners in the initiation and propagation of autoimmune rheumatic diseases, fate mapping and quantitation of hematopoiesis in vivo, coinhibitory pathways in immunotherapy for cancer, and broadly neutralized antibodies to HIV and their role in vaccine design.