The most known are vimentin, synemin, nestin, syncoilin, skelemin, plectin
The N-terminus of Nesprin-3 binds to plectin
, a cytoskeletal crosslinker that establishes the connection to the intermediate filament system .
The genetic defects affect different proteins with essential roles in muscle development and function: defects of structural proteins (laminin-[alpha]2, collagen, integrin, and plectin
), defects of glycosylation (Walker-Warburg syndrome, muscle-eye brain disease, and Fukuyama CMD), proteins of the endoplasmic reticulum and nucleus (selenoprotein, selenocysteine insertion sequence-binding protein 2, laminin A/C), and mitochondrial membrane protein (choline kinase beta).
Kordeli, "Novel interactions of ankyrins-G at the costameres: the muscle-specific obscurin/titin-binding-related domain (OTBD) binds plectin
and filamin C," Experimental Cell Research, vol.
However, autoantibodies against various targets can be found, including desmosomal proteins Dsg1 and Dsg3, plakin family proteins (periplakin, envoplakin, plectin
, desmoplakin, and BP180), and the protease inhibitor alpha-2-macroglobulin-like antigen 1 (A2ML1) (3, 20, 23).
Although annexin A10 and plectin
1 IHC are both positive in (>75%) PDACs, they are not used routinely.
Korkusuz et al., "Mutation in exon 1f of PLEC, leading to disruption of plectin
isoform 1f, causes autosomal-recessive limb-girdle muscular dystrophy," American Journal of Human Genetics, vol.
The only mutation with high variant allele frequency involved the PLEC gene (R1801Q), encoding the cytoskeleton linker protein plectin
. PLEC mutation analysis confirmed that it is present at an early stage of AML-MSC expansion.
Lampel et al., "Identification of the cytolinker plectin
as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis," Molecular and Cellular Biology, vol.
Tenders are invited for Supply of FITC Kits FITC C1q,FITC C3,FITC C4d,FITC Fibrinogen,FITC IgA,FITC IgG,FITC IgM,FITC Kappa,FITC Lamda,FITC SV40,FITC Anti CMV,FITC CK14,FITC Laminin 332,FITC Anticollagen type IV,FITC Anticollagen type VII,FITC Rabbit F (ab) 2 antimouse,FITC Antibody against Bullous pemphigoid antigen BPAg2 (type XVII collagen),FITC Antibody against a64 integrin Recombinant Mouse Integrin alpha 6 beta 4,FITC Antibody against Plectin
,Tween 20- Washing Soloution (sample to be submitted) H.
Supply Of Fitc Kits Fitc C1q,fitc C3,fitc C4d,fitc Fibrinogen,fitc Iga,fitc Igg,fitc Igm,fitc Kappa,fitc Lamda,fitc Sv40,fitc Anti Cmv,fitc Ck14,fitc Laminin
Other molecules studied by  are plakins, which represent a family of molecules which form the links between filaments, desmosomes, and hemidesmosomes and plectin
is a cytolinker of this family.
the membrane protein [beta]-dystroglycan [38, 39] and to several other proteins such as plectin
, ankyrin  and the intermediate filament protein synemin .