PDGFRB

(redirected from platelet-derived growth factor receptor beta)

PDGFRB

A gene on chromosome 5q33.1 that encodes a tyrosine-protein kinase which acts as a cell surface receptor for homodimeric PDGFB and PDGFD and for PDGFA and PDGFB heterodimers, playing a key role in regulating embryonic development; cell proliferation, survival, differentiation, chemotaxis and migration; blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells; and migration of vascular smooth muscle cells and formation of neointima at sites of vascular injury sites. It is required for normal development of the cardiovascular system, for recruitment of mesangial cells and for development of the capillary network in the glomeruli.
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AMG 706 is a potent, oral, small molecule angiogenesis inhibitor that selectively targets multiple kinases, including VEGFr, platelet-derived growth factor receptor beta (PDGFrB, PDGFr), Kit, and Ret.

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