platelet transfusion refractoriness

platelet transfusion refractoriness

A failure of circulating platelet levels to rise after platelet transfusion. Alloimmunization against platelet antigens, disseminated intravascular coagulation, fever, hypersplenism, and sepsis are among the potential causes. A typical platelet transfusion should normally raise platelet counts by more than 20,000 platelets/microliter.
References in periodicals archive ?
rFVIIa is effective for severe bleeding in Glanzmann thrombasthenia patients, especially in those with antiplatelet antibodies and/or platelet transfusion refractoriness. (1)
Thrombocytopenia is closely related to bleeding episodes in patients following HSCT.2,3 If platelet refractoriness is associated with GI bleeding, routine hemostatic interventions may not help.11 Most patients in our case series remained dependent on platelet transfusion, five patients became platelet transfusion refractoriness, which would contribute to the failure of the hemostatic therapy.