neonatal thrombocytopenia

(redirected from platelet production)

neonatal thrombocytopenia

A state that is the most common cause of purpura during the neonatal period, defined by platelets < 150,000/µL
Neonatal thrombocytopenia–causes
Platelet consumption
• Immune-mediated Autoimmune, alloimmune–ITP or SLE in mother, platelet antibodies from mother
• Nonimmune Thrombin generation, infections
platelet production Amegakaryocytic thrombocytopenia, aplastic anemia, myeloinfiltrative processes
Others Drugs, hypoxia, inherited metabolic disorders, hypersplenism, associated with giant hemangiomas–Kasabach-Merritt syndrome  
References in periodicals archive ?
Certain populations such as those with underlying vascular disease and diabetic patients are known to have even higher platelet production rates, making them even more prone to persistent platelet-induced thrombotic vulnerability.
The FDA recommends that health care providers obtain complete blood counts prior to starting each treatment cycle of Lonsurf and monitor patients throughout treatment, as Lonsurf may cause a severe decrease in blood cell and platelet production (myelosuppression).
These include involvement of the bone marrow by opportunistic infections and malignancies and increased incidences of immune thrombocytopenia (ITP) and thrombotic thrombocytopenic purpura (TTP), as well as impaired platelet production as a result of both HIV-associated stromal cell dysfunction [3] and direct HIV infection of megakaryocytes.
To the best of our knowledge this is a novel finding, which may lead to further insight in how megakaryocyte maturation and platelet production change with age.
The agreement allowed the hospital to use the INTERCEPT Blood System to treat its platelet production of around 5,600 units per year.
whether caused by decreased bone marrow platelet production or increased peripheral destruction).
Platelet production in reactive thrombocytosis is increased by an elevation of thrombopoietin secondary to inflammation, infection, neoplastic conditions or stress.
Evidence of accelerated platelet production and consumption in nonthrombocytopenic preeclampsia.
Some examples of specific topics include derivation and manipulation of murine embryonic stem cells, efficient gene knockdowns in human embryonic stem cells using lentiviral-based RNAi, ex vivo megakaryocyte expansion and platelet production from human cord blood stem cells, isolation and manipulation of mammalian neural stem cells in vitro, regeneration of skin and cornea by tissue engineering, template DNA- strand co-segregation and asymmetric cell division in skeletal muscle stem cells, derivation of contractile smooth muscle cells from embryonic stem cells, and reprogramming of liver to pancreas.
It has been an enormous boon to the management of these patients to be able to show that some of the ones who fail immunosuppressive therapy in fact respond to an agent that increases platelet production," said Dr.
A number of conditions cause a low level of natural platelet production or an increase in platelet destruction.

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