neonatal thrombocytopenia

(redirected from platelet production)

neonatal thrombocytopenia

A state that is the most common cause of purpura during the neonatal period, defined by platelets < 150,000/µL
Neonatal thrombocytopenia–causes
Platelet consumption
• Immune-mediated Autoimmune, alloimmune–ITP or SLE in mother, platelet antibodies from mother
• Nonimmune Thrombin generation, infections
platelet production Amegakaryocytic thrombocytopenia, aplastic anemia, myeloinfiltrative processes
Others Drugs, hypoxia, inherited metabolic disorders, hypersplenism, associated with giant hemangiomas–Kasabach-Merritt syndrome  
References in periodicals archive ?
It can result due to immune response against platelet to decreased platelet production.
Thrombocytopenia, a major feature of dengue fever results from decreased platelet production from bone marrow suppression or increased platelet destruction.
The subject of the public contract is: (a) supply of blood-filled and blood-plate-forming bags - triple the number of 25 200 pieces, - 4 pcs in 48 000 pieces, - mixing bag for buffy-coat platelet production of 3600 units, - thrombocyte retention solution of 3600 units; b) free borrowing and installation of 3-5 pcs (according to press capacity) of a new automatic press for processing / separation of collected blood and buffy coat for working with blood bags with upper / lower outlet / (the client specifies the need for processing on 100 blood during 2.
ET is a rare, chronic blood cancer characterized by increased platelet production, a white cell count above the normal range, persistently elevated platelet counts with normal red blood cell mass, and the absence of prominent bone marrow fibrosis.
10] Furthermore, it is shown to influence platelet production and aggregation by activating arachidonate 12-lipoxygenase (ALOX 12) and platelet-activating factor receptor (PTAFR) genes.
They are less capable of responding to distress and the demand for increased platelet production," Goldfarb said.
Many diseases can lead to a decreased platelet production in the bone marrow.
Major cause of thrombocytopenia in ITP is accelerated platelet destruction and impaired platelet production.
It is believed to stimulate platelet production by acting on megakaryocytes and their precursors.
9] The two mechanisms involved in HIV-associated TCP are thought to be immune-mediated destruction of platelets (in early infection) and a defect in platelet production (in advanced disease).
sup][4] In these cases, the proposed pathophysiology was as follows: in humans, exogenous epinephrine promotes platelet aggregation by increasing platelet production from thromboxane B2, heightening the sensitivity of platelets to ADP and promoting the thrombin-induced binding of platelets to fibrinogen.
PDW: Platelet Distribution Width measures the uniformity of platelet size to help evaluate platelet production.

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