platelet glycoprotein IV deficiency
platelet glycoprotein IV deficiencyAn inherited haematologic disorder (OMIM:608404) characterised by a complete type I (complete CD36 deficiency) phenotype, in which platelets and monocytes/macrophages have no CD36, and type II (partial CD36 deficiency) phenotype, in which there is no surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.
Defects in CD36, which encodes the fourth major platelet surface glycoprotein (PGIV), a receptor for thrombospondin, cause platelet glycoprotein deficiency.
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