ITGB3

(redirected from platelet glycoprotein IIIa)

ITGB3

A gene on chromosome 17q25 that encodes an integrin beta chain protein (integrins are noncovalently associated transmembrane glycoprotein receptors, composed one of 18 different alpha and one of 8 different beta chains). The beta-3 chain partners with the alpha-IIb chain and acts as a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin, vitronectin and platelets. Beta-3 chain partnered with the alpha-5 chain is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor.
References in periodicals archive ?
Kieffer, "Early immunization against platelet glycoprotein IIIa in a newborn Glanzmann type I patient," Vox Sanguinis, vol.
The mRNAs included control housekeeping genes [actin, beta (ACTB) [4] and beta-2-microglobulin (B2M)] and myeloid [defensin, alpha 3, neutrophil-specific (DEFA3) and serglycin (SRGN)], erythroid [hemoglobin, beta (HBB) and uroporphyrinogen decarboxylase (UROD)], and megakaryocyte [integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) (ITGA2B) and integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ITGB3)] lineage-specific genes.
[4] Human genes: ACTB, actin, beta; B2M, beta-2-microglubulin; DEFA3, defensin, alpha 3, neutrophil-specific; SRGN, serglycin; HBB, hemoglobin, beta; UROD, uroporphyrinogen decarboxylase; ITGA2B, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); ITGB3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); CD34, CD34 molecule; CD3E, CD3e molecule, epsilon (CD3-TCR complex); CD4, CD4 molecule; CD8A, CD8a molecule; CD19, CD19 molecule.
PlA1/ A2 polymorphism of platelet glycoprotein IIIa and risks of myocardial infarction, stroke, and venous thrombosis.
* Molecular analysis is available for identifying mutations in the ITGA2B and ITGB3 [integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)] genes and is important for genetic counseling.
Staining Characteristics of Acute Megakaryotic Leukemia Blasts and Micromegakaryocytes Cytochemistry Immunophenotype (-) Sudan black B (+) Platelet glycoprotein Ib (CD42b) (-) Myeloperoxidase (+) Platelet glycoprotein IIb/ IIIa (CD41) (-) Terminal (+) Platelet glycoprotein IIIa deoxynucleotidyltransferase (CD61) (+) Periodic acid-Schiff, (+) Factor VIII-related antigen acid phosphatase (+/-) Nonspecific esterase (+/-) HLA-DR, CD33, CD34 (focal, paranuclear)

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