* Platelet adhesion
then initiates the expression of platelet adhesive receptors, such as II3, P-selectin and
Deng, "Swirling flow created in a glass tube suppressed platelet adhesion
to the surface of the tube: its implication in the design of small-caliber arterial grafts," Thrombosis Research, vol.
Also, intact vascular endothelium prevents platelet adhesion
and balances between the secretion of procoagulant/anti-coagulant and profibrinolitic/antifibrinolytic substances contributing to the equilibrium of coagulation and fibrinolysis .
In case of colloids (mainly dextrans, starches and gelatines), a transient decrease in factor VIII amounts, acquired von Willebrand syndrome, impaired thrombin-fibrinogen interactions, impaired factor XIII-fibrin polymer interactions and decreased platelet adhesion
and aggregation, with impairment of primary and secondary haemostasis, have been described (6, 7).
Molecules that disturb the interaction between VWF and GpIb, like monoclonal antibodies AJvW-2  and AJW200 , the VWF recombinant fragment VCL , and ATA (aurintricarboxylic acid)  have shown to prevent neointima formation and growth, by inhibiting platelet adhesion
to the vessel wall and SMC proliferation.
To study microvascular inflammation, we assessed sepsis-induced leukocyte and platelet adhesion
in small intestinal microcirculation of SIRT2KO and SIRT2KI mice compared to those of WT control.
Moncada, "Endogenous nitric oxide inhibits human platelet adhesion
to vascular endothelium," Lancet, vol.
Oliviero et al., "Increased platelet adhesion
and thrombus formation in a mouse model of Alzheimer's disease," Cellular Signalling, vol.
The initial step of platelet adhesion
in thrombogenesis is very important and determines mural thrombosis that occurs assisted by other blood cells in later steps .
The protein adsorption, platelet adhesion
, clotting times (activated partial thromboplastin times (APTTs) and thrombin times (TTs)), platelet activation (Human Platelet Factor 4 (PF4)), coagulation activation (thrombin-antithrombin III complex (TAT)), and complement activation (C3a and C5a) of PES membranes were carried out, and the details were provided in S2 (see Supplementary Material).
Increased platelet adhesion
in the experimental rats should be associated with overexpression of the receptors to von Willebrand factor on their surface.
endothelial VWF to platelet adhesion