plasminogen activator


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Related to plasminogen activator: streptokinase, Plasminogen activator inhibitor

plasminogen activator

 [plaz-min´o-jen ak´tĭ-va″tor]
any of a group of substances that cleave plasminogen and convert it to plasmin, its active form, e.g., tissue plasminogen activator.

plas·min·o·gen ac·ti·va·tor

a proteinase converting plasminogen to plasmin by cleavage of an Arg-Val bond in the former.
Synonym(s): urokinase

plas·min·o·gen ac·ti·va·tor

(plaz-min'ŏ-jen ak'ti-vā-tŏr)
A proteinase that converts plasminogen to plasmin by cleavage of a single (usually Arg-Val) bond in the former. Prevents formation of fibrin clots. Alteplase and streptokinase are examples of medications that promote thrombolysis by activating plasminogen.
Synonym(s): urokinase.

plas·min·o·gen ac·ti·va·tor

(plaz-min'ŏ-jen ak'ti-vā-tŏr)
A proteinase that converts plasminogen to plasmin and prevents formation of fibron clots.
Synonym(s): urokinase.
References in periodicals archive ?
Prognostic value analysis of urokinase-type plasminogen activator receptor in oral squamous cell carcinoma: an immunohistochemical study.
Bhatacharjee, "Imbalance between protective (adiponectin) and prothrombotic (plasminogen activator inhibitor-1) adipokines in metabolic syndrome," Diabetes & Metabolic Syndrome: Clinical Research & Reviews, vol.
Eugen-Olsen et al., "Soluble urokinase plasminogen activator receptor is in contrast to high-sensitive C-reactive-protein associated with coronary artery calcifications in healthy middle-aged subjects," Atherosclerosis, vol.
Elokdah et al., "Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor," Journal of Biological Chemistry, vol.
Booth, "Characterization of crosslinking sites in fibrinogen for plasminogen activator inhibitor 2 (PAI-2)," Annals of the New York Academy of Sciences, vol.
Racial and ethnic disparities in the use of intravenous recombinant tissue plasminogen activator and outcomes for acute ischemic stroke.
The role of plasminogen activator inhibitor 1 in renal and cardiovascular diseases.
* The report reviews Plasminogen Activator Inhibitor-1 (Endothelial Plasminogen Activator Inhibitor or Serpin E1 or PAI-1) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Eligibility for recombinant tissue plasminogen activator in acute ischemic stroke: a population- based study.
They examined the role of plasminogen activator, which is commonly known in the UK as alteplase.
SAN DIEGO - The percentage of patients arriving at hospitals with ischemic stroke who were treated with tissue plasminogen activator within the recommended 60 minutes increased from 30% to 53% on average at 1,030 hospitals engaged in the Target: Stroke program in the past 4 years.

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