plasminogen activation system

plasminogen activation system

The cascade that regulates the conversion of plasminogen to the proteinase plasmin. It involves a urokinase-type plasminogen activator, a tissue-type activator and at least two inhibitors.
References in periodicals archive ?
uPAR regulates the plasminogen activation system by binding urokinase (uPA) and its zymogen form, pro-UPA [79].
PAI-1 is the main inhibitor in the plasminogen activation system, which comprises an inactive proenzyme (plasminogen) that can be converted into its active form the plasmin, by the action of physiological plasminogen activators; plasmin is the main enzyme that degrades fibrin into soluble products (8).
Petersen, "The plasminogen activation system in tumor growth, invasion, and metastasis," Cellular and Molecular Life Sciences, vol.
Sunkar, "Vascular functions of the plasminogen activation system," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Two interrelated proteolytic systems are involved in matrix degradation: the plasminogen activation system and the matrix metalloproteinase system.
The plasminogen activation system is active in a number of nonpathologic tissue-remodeling processes, including wound healing (1) and postlactation mammary gland involution (2), whereas uncontrolled activity of the plasminogen activation system has been observed during pathologic conditions, including cancer invasion and metastasis (3).
Among the key players in the proteolytic cascade leading tumour invasion and metastasis are factors of the plasminogen activation system (1).
An ELISA avoiding interference by heterophilic antibodies in the measurement of components of the plasminogen activation system in blood.
Evidence for a linkage of expression of the genes of the plasminogen activation system is also present at the molecular level.
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