plasminogen activation system

The cascade that regulates the conversion of plasminogen to the proteinase plasmin. It involves a urokinase-type plasminogen activator, a tissue-type activator and at least two inhibitors.

References in periodicals archive ?

Two interrelated proteolytic systems are involved in matrix degradation: the plasminogen activation system and the matrix metalloproteinase system.

Paeoniflorin of Paeonia lactiflora prevents renal interstitial fibrosis induced by unilateral ureteral obstruction in mice

The plasminogen activation system is active in a number of nonpathologic tissue-remodeling processes, including wound healing (1) and postlactation mammary gland involution (2), whereas uncontrolled activity of the plasminogen activation system has been observed during pathologic conditions, including cancer invasion and metastasis (3).

A new assay for measurement of the liberated domain I of the urokinase receptor in plasma improves the prediction of survival in colorectal cancer

Among the key players in the proteolytic cascade leading tumour invasion and metastasis are factors of the plasminogen activation system (1).

Relation of serum vascular endothelial growth factor as an angiogenesis biomarker with nitric oxide & urokinase-type plasminogen activator in breast cancer patients

Post-transcriptional regulation of gene expression in the plasminogen activation system.

Purification of c-phycocyanin from Spirulina fusiformis and its effect on the induction of urokinase-type plasminogen activator from calf pulmonary endothelial cells

An ELISA avoiding interference by heterophilic antibodies in the measurement of components of the plasminogen activation system in blood.

Concerns about mammaglobin assays

Evidence for a linkage of expression of the genes of the plasminogen activation system is also present at the molecular level.

To our knowledge, this is the first report of a possible role for blackseed oil in modulating the plasminogen activation system in a tumor cell line and of a possible therapeutic role for Nigella sativa oil modulation of the fibrinolytic potential of fibrosarcoma.

In vitro decreases of the fibrinolytic potential of cultured human fibrosarcoma cell line, HT1080, by Nigella sativa oil

The amounts of uPAR fragments in tissues and circulation may reflect the activity of the plasminogen activation system and thus have a stronger prognostic significance than the traditional measurements of only the total uPAR content.

Specific immunoassays for detection of intact and cleaved forms of the urokinase receptor

Clinical impact of the plasminogen activation system in tumor invasion and metastasis: prognostic relevance and target for therapy.

Urokinase plasminogen activator and its inhibitor, PAI-1, as prognostic markers in breast cancer: from pilot to level I evidence studies

The plasminogen activation system and matrix metalloproteinases (MMPs)[3] play a key role in the degradation of basement membrane and extracellular matrix in tissue remodeling, cancer cell invasion, and metastasis (2).

Quantitative real-time reverse transcription-PCR assay for urokinase plasminogen activator, plasminogen activator inhibitor type 1, and tissue metalloproteinase inhibitor type 1 gene expressions in primary breast cancer

The plasminogen activation system plays a central role in several tissue remodeling processes, including cancer invasion.

Determination of the complex between urokinase and its type-I inhibitor in plasma from healthy donors and breast cancer patients

Cell-induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH2-terminal domain of the urokinase receptor.

ELISA determination of soluble urokinase receptor in blood from healthy donors and cancer patients

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