plasminogen activation system

plasminogen activation system

The cascade that regulates the conversion of plasminogen to the proteinase plasmin. It involves a urokinase-type plasminogen activator, a tissue-type activator and at least two inhibitors.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The plasminogen activation system and gastric cancer
Relevance of the plasminogen activation system in the pathogenesis and progression of gastric cancer
uPAR regulates the plasminogen activation system by binding urokinase (uPA) and its zymogen form, pro-UPA [79].
Soluble Urokinase Receptor and the Kidney Response in Diabetes Mellitus
PAI-1 is the main inhibitor in the plasminogen activation system, which comprises an inactive proenzyme (plasminogen) that can be converted into its active form the plasmin, by the action of physiological plasminogen activators; plasmin is the main enzyme that degrades fibrin into soluble products (8).
Un haplogenotipo de PAI-1 confiere susceptibilidad genetica para la obesidad y la hipertrigliceridemia en ninos mexicanos
Petersen, "The plasminogen activation system in tumor growth, invasion, and metastasis," Cellular and Molecular Life Sciences, vol.
Functional stability of plasminogen activator inhibitor-1
Sunkar, "Vascular functions of the plasminogen activation system," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Expression of uPA, tPA, and PAI-1 in calcified aortic valves
Two interrelated proteolytic systems are involved in matrix degradation: the plasminogen activation system and the matrix metalloproteinase system.
Paeoniflorin of Paeonia lactiflora prevents renal interstitial fibrosis induced by unilateral ureteral obstruction in mice
The plasminogen activation system is active in a number of nonpathologic tissue-remodeling processes, including wound healing (1) and postlactation mammary gland involution (2), whereas uncontrolled activity of the plasminogen activation system has been observed during pathologic conditions, including cancer invasion and metastasis (3).
A new assay for measurement of the liberated domain I of the urokinase receptor in plasma improves the prediction of survival in colorectal cancer
The urokinase-mediated plasminogen activation system plays a central role in breaking down the extracellular matrix; this process might be a valuable anticancer strategy.
PEG-ging peptides: peptides seem so promising as drug candidates. Their small size, however, makes delivery difficult and gives them an extremely short half-life--the kidneys or reticuloendothelial system often clears them only minutes after being administered. They are also susceptible to degradation by proteolytic enzymes. Linking them to polyethylene glycol (PEG) can solve these problems
Among the key players in the proteolytic cascade leading tumour invasion and metastasis are factors of the plasminogen activation system (1).
Relation of serum vascular endothelial growth factor as an angiogenesis biomarker with nitric oxide & urokinase-type plasminogen activator in breast cancer patients
Post-transcriptional regulation of gene expression in the plasminogen activation system. Biol.
Purification of c-phycocyanin from Spirulina fusiformis and its effect on the induction of urokinase-type plasminogen activator from calf pulmonary endothelial cells
An ELISA avoiding interference by heterophilic antibodies in the measurement of components of the plasminogen activation system in blood.
Concerns about mammaglobin assays
Evidence for a linkage of expression of the genes of the plasminogen activation system is also present at the molecular level.
In vitro decreases of the fibrinolytic potential of cultured human fibrosarcoma cell line, HT1080, by Nigella sativa oil
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