plasminogen activation system

plasminogen activation system

The cascade that regulates the conversion of plasminogen to the proteinase plasmin. It involves a urokinase-type plasminogen activator, a tissue-type activator and at least two inhibitors.
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Two interrelated proteolytic systems are involved in matrix degradation: the plasminogen activation system and the matrix metalloproteinase system.
The plasminogen activation system is active in a number of nonpathologic tissue-remodeling processes, including wound healing (1) and postlactation mammary gland involution (2), whereas uncontrolled activity of the plasminogen activation system has been observed during pathologic conditions, including cancer invasion and metastasis (3).
Among the key players in the proteolytic cascade leading tumour invasion and metastasis are factors of the plasminogen activation system (1).
An ELISA avoiding interference by heterophilic antibodies in the measurement of components of the plasminogen activation system in blood.
Evidence for a linkage of expression of the genes of the plasminogen activation system is also present at the molecular level.
To our knowledge, this is the first report of a possible role for blackseed oil in modulating the plasminogen activation system in a tumor cell line and of a possible therapeutic role for Nigella sativa oil modulation of the fibrinolytic potential of fibrosarcoma.
The amounts of uPAR fragments in tissues and circulation may reflect the activity of the plasminogen activation system and thus have a stronger prognostic significance than the traditional measurements of only the total uPAR content.
Clinical impact of the plasminogen activation system in tumor invasion and metastasis: prognostic relevance and target for therapy.
The plasminogen activation system and matrix metalloproteinases (MMPs)[3] play a key role in the degradation of basement membrane and extracellular matrix in tissue remodeling, cancer cell invasion, and metastasis (2).
The plasminogen activation system plays a central role in several tissue remodeling processes, including cancer invasion.
Cell-induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH2-terminal domain of the urokinase receptor.
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