The
plasminogen activation system and gastric cancer
uPAR regulates the
plasminogen activation system by binding urokinase (uPA) and its zymogen form, pro-UPA [79].
PAI-1 is the main inhibitor in the
plasminogen activation system, which comprises an inactive proenzyme (plasminogen) that can be converted into its active form the plasmin, by the action of physiological plasminogen activators; plasmin is the main enzyme that degrades fibrin into soluble products (8).
Petersen, "The
plasminogen activation system in tumor growth, invasion, and metastasis," Cellular and Molecular Life Sciences, vol.
Sunkar, "Vascular functions of the
plasminogen activation system," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Two interrelated proteolytic systems are involved in matrix degradation: the
plasminogen activation system and the matrix metalloproteinase system.
The
plasminogen activation system is active in a number of nonpathologic tissue-remodeling processes, including wound healing (1) and postlactation mammary gland involution (2), whereas uncontrolled activity of the
plasminogen activation system has been observed during pathologic conditions, including cancer invasion and metastasis (3).
The urokinase-mediated
plasminogen activation system plays a central role in breaking down the extracellular matrix; this process might be a valuable anticancer strategy.
Among the key players in the proteolytic cascade leading tumour invasion and metastasis are factors of the
plasminogen activation system (1).
Post-transcriptional regulation of gene expression in the
plasminogen activation system. Biol.
An ELISA avoiding interference by heterophilic antibodies in the measurement of components of the
plasminogen activation system in blood.
Evidence for a linkage of expression of the genes of the
plasminogen activation system is also present at the molecular level.