plasminogen


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plasminogen

 [plaz-min´o-jen]
the inactive precursor of plasmin, occurring in plasma and converted to plasmin by the action of urokinase; called also profibrinolysin.

plas·min·o·gen

(plaz-min'ō-jen), [MIM*173350]
A precursor of plasmin. There is an autosomal dominant deficiency of plasminogen [MIM*173350] that may promote thrombosis.
See: plasmin.

plasminogen

/plas·min·o·gen/ (plaz-min´ah-jen) the inactive precursor of plasmin, occurring in plasma and converted to plasmin by the action of urokinase.

plasminogen

(plăz-mĭn′ə-jən)
n.
The inactive precursor to plasmin that is found in body fluids and blood plasma.

plasminogen

inactive precursor of plasmin, the enzyme that digests fibrinogen during fibrinolysis. See fibrinogen.

plasminogen

An 88 kD single-stranded plasmin proenzyme present in the circulation which is converted to plasmin by cleavage of the Arg-Val bond; it is synthesized in the liver, produced or stored in eosinophils and forms complexes with fibrinogen and fibrin; during coagulation, large amounts of plasminogen are integrated in the fibrin clot ↑ in DVT, infection, inflammation, CA, MI, OCs, pregnancy, physical stress, surgery, trauma ↓ in Cirrhosis, other liver disease, DIC, fibrinolysis, hyaline membrane disease–RDS of newborn, renal disease, post-surgery–eg, CABG, thrombosis Normal 2.5-5.2 U/mL–US: 20 mg/dL

plas·min·o·gen

(plaz-min'ŏ-jen)
A precursor of plasmin; an autosomal dominant deficiency of plasminogen that may promote thrombosis.
See also: plasmin

plasminogen

The precursor to PLASMIN.

plas·min·o·gen

(plaz-min'ŏ-jen) [MIM*173350]
A precursor of plasmin; may promote thrombosis.

plasminogen (plazmin´ōjen),

n the precursor of plasmin found in plasma. It is probably activated by a tissue factor or by a blood activator, which first must be activated by a blood or tissue fibrinolysokinase. Formerly called
profibrinolysin. See also plasmin.

plasminogen

the inactive precursor of plasmin, occurring in plasma and converted to plasmin by activators present in most tissues, blood, vessel walls and body fluids; called also profibrinolysin.

plasminogen activator inhibitor
can protect the fibrin clot from premature lysis; called also PA inhibitor.
References in periodicals archive ?
Results from the two-dimensional SDS-PAGE analysis showed the return of the possible plasminogen polymer to the region of the monomeric plasminogen standard, at around a molecular weight of 90,000 Da.
Muscle tPA activity, assessed by plasminogen gel zymography, did not significantly change with exercise (Figure 2A).
Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases.
Use of tissue-type plasminogen activator for acute ischemic stroke: the Cleveland area experience.
Activated plasminogen, plasmin, is a fundamental component of the fibrinolytic system and is the main enzyme involved in the lysis of blood clots and clearance of extravasated fibrin.
According to the company, its plasminogen replacement therapy has been granted Orphan Drug and Fast Track Designations by the US FDA.
The License Agreement needed readjustment as the timing of investments and milestone payments related to the plasminogen development program and those relating to the CMO relationship became unreasonably out of sync", stated Pierre Laurin, President and Chief Executive Officer of ProMetic.
Omnio scientists in Sweden have clearly demonstrated the remarkable effect of a local plasminogen micro-injection around the perforation on the eardrum in multiple preclinical models.
It occurs due to type 1 plasminogen deficiency and may present as a systemic disease involving other mucous membranes besides the conjunctiva (1,2).
The fibrinolytic (plasminogen/plasmin) system in the vasculature includes an inactive proenzyme, plasminogen (Pg), which can be converted into the active enzyme, plasmin (Pm), which degrades fibrin into soluble degradation products (2).

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