plasminogen


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Related to plasminogen: tissue plasminogen activator, thrombin, Plasminogen activator inhibitor

plasminogen

 [plaz-min´o-jen]
the inactive precursor of plasmin, occurring in plasma and converted to plasmin by the action of urokinase; called also profibrinolysin.

plas·min·o·gen

(plaz-min'ō-jen), [MIM*173350]
A precursor of plasmin. There is an autosomal dominant deficiency of plasminogen [MIM*173350] that may promote thrombosis.
See: plasmin.

plasminogen

/plas·min·o·gen/ (plaz-min´ah-jen) the inactive precursor of plasmin, occurring in plasma and converted to plasmin by the action of urokinase.

plasminogen

(plăz-mĭn′ə-jən)
n.
The inactive precursor to plasmin that is found in body fluids and blood plasma.

plasminogen

inactive precursor of plasmin, the enzyme that digests fibrinogen during fibrinolysis. See fibrinogen.

plasminogen

An 88 kD single-stranded plasmin proenzyme present in the circulation which is converted to plasmin by cleavage of the Arg-Val bond; it is synthesized in the liver, produced or stored in eosinophils and forms complexes with fibrinogen and fibrin; during coagulation, large amounts of plasminogen are integrated in the fibrin clot ↑ in DVT, infection, inflammation, CA, MI, OCs, pregnancy, physical stress, surgery, trauma ↓ in Cirrhosis, other liver disease, DIC, fibrinolysis, hyaline membrane disease–RDS of newborn, renal disease, post-surgery–eg, CABG, thrombosis Normal 2.5-5.2 U/mL–US: 20 mg/dL

plas·min·o·gen

(plaz-min'ŏ-jen)
A precursor of plasmin; an autosomal dominant deficiency of plasminogen that may promote thrombosis.
See also: plasmin

plasminogen

The precursor to PLASMIN.

plas·min·o·gen

(plaz-min'ŏ-jen) [MIM*173350]
A precursor of plasmin; may promote thrombosis.

plasminogen (plazmin´ōjen),

n the precursor of plasmin found in plasma. It is probably activated by a tissue factor or by a blood activator, which first must be activated by a blood or tissue fibrinolysokinase. Formerly called
profibrinolysin. See also plasmin.

plasminogen

the inactive precursor of plasmin, occurring in plasma and converted to plasmin by activators present in most tissues, blood, vessel walls and body fluids; called also profibrinolysin.

plasminogen activator inhibitor
can protect the fibrin clot from premature lysis; called also PA inhibitor.
References in periodicals archive ?
This case provides a clear demonstration of the efficacy of our plasminogen product in a very serious clinical situation.
Treatment of neonatal thrombus formation with recombinant tissue plasminogen activator: six years experience and review of the literature.
Plasminogen activator inhibitor-1 is elevated in the children of men with premature myocardial infarction.
Researchers from Monash University and the Australian Synchrotron have now solved the long-sought-after atomic structure of closed plasminogen.
The results from the one-dimensional SDS-PAGE revealed the existence of high molecular weight bands that the scientists suspected to be plasminogen.
Expression of urokinase plasminogen activator, its receptor and type-1 inhibitor in malignant and benign prostate tissue.
Induction of urokinase-type plasminogen activator by the anthracycline antibiotic in human RC-K8 lymphoma and H69 lung-carcinoma cells.
Currently in the United States, a drug called recombinant tissue plasminogen activator (rt-PA) is approved for treating strokes which have been caused by clots blocking blood flow to the brain.
Urokinasetype Plasminogen Activator (uPA) has been speculated to convert plasminogen into plasmin, which degrades the extracellular matrix and provides a pathway through which neural crest cells migrate.
They discovered that a common blood protein, plasminogen, sticks to rogue prions but ignores the normal variety.
Plasminogen plays an important role in early regeneration and wound repair in vertebrates, and there are similarities between echinoderm coelomocytes and the immune systems of vertebrates.

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