plasmin


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Related to plasmin: plasminogen, fibrinogen

plasmin

 [plaz´min]
the active principle of the fibrinolytic or clot-lysing system, a proteolytic enzyme with a high specificity for fibrin and the particular ability to dissolve formed fibrin clots.

plas·min

(plaz'min),
A serine proteinase catalyzing the hydrolysis of peptides and of esters of l-arginine and l-lysine and converting fibrin to soluble products; occurs in plasma as the precursor plasminogen (profibrinolysin) and is activated to plasmin by organic solvents, which remove an inhibitor, and by streptokinase, trypsin, and plasminogen activator, all cleaving a single arginyl-valyl bond; plasmin is responsible for the dissolution of blood clots.
Synonym(s): fibrinase (2) , fibrinolysin

plasmin

/plas·min/ (plaz´min) an endopeptidase occurring in plasma as plasminogen, which is activated via cleavage by plasminogen activators; it solubilizes fibrin clots, degrades other coagulation-related proteins, and can be activated for use in therapeutic thrombolysis.

plasmin

(plăz′mĭn)
n.
A proteolytic enzyme that is formed from plasminogen in blood plasma and dissolves the fibrin in blood clots. Also called fibrinolysin.

plasmin

plasmin

A proteolytic enzyme formed from plasminogen that lyses blood clots; plasmin exists in free and bound–fibrin-adsorbed forms; the former is destroyed as it is formed by antiplasmins, the latter acts as a serine endopeptidase to solubilize fibrin clots; it hydrolyzes lysine and arginine bonds in certain proteins–eg, fibrinogen, coagulation factors V and VII. See tPA.

plas·min

(plaz'min)
An enzyme hydrolyzing peptides and esters of l-arginine and l-lysine, and converting fibrin to soluble products; responsible for the dissolution of blood clots.
Synonym(s): fibrinase (2) , fibrinolysin.

plasmin

A protein-splitting enzyme in the blood that dissolves FIBRIN clots.

plasmin

enzyme formed from plasma fibrinogen; converts insoluble fibrin to soluble products, as part of clot lysis

plas·min

(plaz'min)
An enzyme responsible for the dissolution of blood clots.
Synonym(s): fibrinase (2) , fibrinolysin.

plasmin (plaz´min),

n collective term for one or more proteolytic enzymes found in the blood. The proteolytic enzymes are capable of digesting fibrin, fibrinogen, and proaccelerin. Plasminogen, the inactive form, may become active spontaneously in shed blood. An activator, fibrinokinase (fibrinolysokinase), is found in many animal tissues. Also called
fibrinolysin, lysin, plasma proteolytic enzyme, and
tryptase. See also plasminogen.

plasmin

the active principle of the fibrinolytic or clot-lysing system, a proteolytic enzyme formed from plasminogen which hydrolyzes fibrin, fibrinogen, factor V and other proteins. It has the particular ability to dissolve formed fibrin clots. Called also fibrinolysin.

plasmin inhibitors
include α2-macroglobulin, α1-antitrypsin, C1-inactivator, antithrombin III.
References in periodicals archive ?
Now days this mechanism is not yet understood, but it is recognized that elevated plasmin levels can reduce the virulence of S.
1973) Proteolytic cleavage by plasmin of a HA polypeptide of influenza virus: host cell activation of serum plasminogen.
Proteolysis and storage stability of UHT milk as influenced by milk plasmin activity, plasmin/AY-lactoglobulin complexation, plasminogen activation and somatic cell count.
28 In the presence of the lysine analogues, plasminogen can still be activated to plasmin, but it is inhibited from binding and degrading fibrin.
Phenomena of proteolysis and epithelial permeability increase the levels of plasmin and other proteases from SC leading to degradation of casein [1].
3] Nonstandard abbreviations: TF, tissue factor; FVIIa, activated factor VII; TM, thrombomodulin; PC, protein C; EPCR, endothelial protein C receptor; APC, activated PC; PS, protein S; AT, antithrombin; TFPI, tissue factor pathway inhibitor; tPA, tissue plasminogen activator; uPA, urokinase plasminogen activator; PAI, plasminogen activator inhibitor; PI, plasmin inhibitor; TAFI, thrombin activatable fibrinolysis inhibitor; ROTEM/TEG, thromboelastometry/thromboelastography; T2MR, T2 magnetic resonance.
The effects of daily oxytocin injections before and after milking on milk production, milk plasmin, and milk composition.
Many pathogenic bacteria have been shown to bind host plasmin to disseminate and cause disease, and we hypothesize that Escherichia coli surface-exposed Lpp can bind plasminogen.
Plasmin cleaves fibrinogen and fibrin monomer into fibrin split products and cross-linked fibrin polymer into Ddimers, respectively, inactivates coagulation factors V and VIII, and has direct effects on platelet membrane receptors.
Lysteda is a nonhormonal lysine analog that acts as a competitive plasmin inhibitor; it is not a contraceptive.
Glutathione reduces the chances of complications associated with diabetes, lung diseases, raising glutathione levels restores normal liver function tranexamic acid (Trans-4-aminomethylcyclohexane Carboxylic acid) a derivative lysine, inhibits the proteolytic activity of plasmin and the conversion of plasminogen to plasmin with the aid of plasminogen activators.
Plasmin is involved in the destruction of the extracellular matrix which is rich in fibrin.