plasmin


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Related to plasmin: plasminogen, fibrinogen

plasmin

 [plaz´min]
the active principle of the fibrinolytic or clot-lysing system, a proteolytic enzyme with a high specificity for fibrin and the particular ability to dissolve formed fibrin clots.

plas·min

(plaz'min),
A serine proteinase catalyzing the hydrolysis of peptides and of esters of l-arginine and l-lysine and converting fibrin to soluble products; occurs in plasma as the precursor plasminogen (profibrinolysin) and is activated to plasmin by organic solvents, which remove an inhibitor, and by streptokinase, trypsin, and plasminogen activator, all cleaving a single arginyl-valyl bond; plasmin is responsible for the dissolution of blood clots.
Synonym(s): fibrinase (2) , fibrinolysin

plasmin

(plăz′mĭn)
n.
A proteolytic enzyme that is formed from plasminogen in blood plasma and dissolves the fibrin in blood clots. Also called fibrinolysin.

plasmin

A proteolytic enzyme formed from plasminogen that lyses blood clots; plasmin exists in free and bound–fibrin-adsorbed forms; the former is destroyed as it is formed by antiplasmins, the latter acts as a serine endopeptidase to solubilize fibrin clots; it hydrolyzes lysine and arginine bonds in certain proteins–eg, fibrinogen, coagulation factors V and VII. See tPA.

plas·min

(plaz'min)
An enzyme hydrolyzing peptides and esters of l-arginine and l-lysine, and converting fibrin to soluble products; responsible for the dissolution of blood clots.
Synonym(s): fibrinase (2) , fibrinolysin.

plasmin

A protein-splitting enzyme in the blood that dissolves FIBRIN clots.

plas·min

(plaz'min)
An enzyme responsible for the dissolution of blood clots.
Synonym(s): fibrinase (2) , fibrinolysin.
References in periodicals archive ?
The members of the plasminogen activation system and the mechanism of plasminogen activation: Binding of pro-uPA to its specific receptor, uPAR, causes the conversion of plasminogen into plasmin, which is achieved by proteolytic cleavage.
Omasu et al., "Glomerular plasminlike activity in relation to nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis," Journal of the American Society of Nephrology, vol.
Cysteine proteases from the Asclepiadaceae plants latex exhibited thrombin and plasmin like activities.
With the recent clinical introduction of ocriplasmin (microplasmin/Jetrea; ThromboGenics, Iselin, NJ) which is a recombinant truncated version of plasmin approved by the US Food and Drug Administration for the treatment of symptomatic vitreomacular traction, one would expect a better outcome of enzyme-assisted PVD in pediatric cases of TMH [57].
Plasmin is a serine proteinase which not only acts on fibrin degradation leading to clot dissolution but also activates MMPs, growth factors, and proteinase-activated receptors ([PAR.sub.1]).
After incubation at 37[degrees]C for 10 min, alteplase (100 IU/ml), plasmin (250 [micro]g/ml), or vehicle was added.
Inhibition of the fibrinolytic system may also occur at the level of plasmin, mainly by [alpha]2-antiplasmin ([alpha]2AP) [10].
A lumbar puncture was then performed which prompted the performance of a rapid plasmin reagent (RPR).
Bovine pancreatic chymotrypsin is the active ingredient in Quimotripsyn[R]--Virbac Laboratories, whose action increases plasmin, a proteolytic enzyme of endothelial origin that is responsible for lysing excess of fibrin from the inflammatory process and is considered as the key of fibrinolysis (16).
2, pancreatic trypsin efficiently activated the infectivity of almost all strains, except IAV WSN/33(H1N1), and mini- and micro-plasmin (which are degradation products of plasmin found in inflammatory loci) also activated all strains though less efficiently than trypsin.
The increase in proteolytic activity is associated with higher activity of plasmin in udders of deteriorating health (Albenzio et al., 2004).
The somatic cells ally themselves with heat-resistant enzymes in the milk called plasmin, which can degrade proteins in a similar way to bacterial enzymes.