Choline serves as a structural constituent of membrane phospholipids (PC, choline plasmalogen
, and sphingomyelin) and also plays an important role in the other biological actions (cholinergic neurotransmission, platelet activating-factor formation, hepatic secretion of VLDL, and methyl transport).
Applications of TLC have recently been reviewed in the context of plasmalogen
oxidation product analysis .
RCDP type 2 and 3 are single enzyme deficiencies in the plasmalogen
RCDP type 2 (OMIM 222765) and 3 (OMIM 600121) are single enzyme deficiencies in the plasmalogen
Peroxisomal disease cell lines with cellular plasmalogen
deficiency have impaired muscarinic cholinergic signal transduction activity and amyloid precursor protein secretion.
Additionally, Manjunath and Therien  found that the BSP proteins, which bind to sperm plasma membrane phospholipids specifically phosphatidylcholine, phophatidylcholine plasmalogen
and sphingomyelin, stimulated cholesterol and phospholipid efflux from the sperm membrane.
found reduced plasmalogen
levels in patients with stable and unstable CAD including a 30% of diabetics patients in the CAD groups, confirming the concept of these metabolites being involved in the clinical setting of CAD .
Heimburger, "Phospholipid plasmalogen
, a surrogate marker of oxidative stress, is associated with increased cardiovascular mortality in patients on renal replacement therapy," Nephrology Dialysis Transplantation, vol.
(1986) Isolation of animal cell mutants deficient in plasmalogen
biosynthesis and peroxisome assembly.
iPL[A.sub.2] prefers plasmalogen
substrates and does not appear to have a preference for the type of fatty acid at the sn-2 position .
Low-concentration ozone reacts with plasmalogen
glycerophosphoethanolamine lipids in lung surfactant.
Ikematsu et al., "Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen
through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways," Biochimica et Biophysica Acta--Molecular and Cell Biology of Lipids, vol.