Low-concentration ozone reacts with plasmalogen
glycerophosphoethanolamine lipids in lung surfactant.
Peroxisomal disease cell lines with cellular plasmalogen
deficiency have impaired muscarinic cholinergic signal transduction activity and amyloid precursor protein secretion.
Analyses of the fatty acid pattern of membrane phospholipids and plasmalogen
of human spermatozoa have demonstrated significant levels of polyunsaturated acids.
Relative high percentages of the plasmalogen
derivatives 16:0DMA and 18:0DMA were also detected.
It mostly exists in the forms of phospholipids phosphatidylcholine (lecithin), lysophosphatidylcholine, choline plasmalogens
and sphingomyelin, and is widely distributed in all plant and animal cells (Zeisel, 1990).
In the chromatograms obtained from base-catalyzed methylations, FFA peaks could be identified clearly in addition to FAME, whereas in the chromatogram obtained from the acid-catalyzed methylations, peaks related to acetals (originating from methanolization of the plasmalogens
contained in the samples) were identified, as confirmed by GC-MS analysis.
Their origin and how they transform, cholesterol, phospholipids, plasmalogens
, polyunsaturated fatty acids, sugars, and proteins into deleterious products.