plasmablast


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plasmablast

 [plaz´mah-blast]
the immature precursor of a plasmacyte, or plasma cell.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

plas·ma·blast

(plaz'mă-blast),
Precursor of the plasma cell.
Synonym(s): plasmacytoblast
[plasma + G. blastos, germ]
Farlex Partner Medical Dictionary © Farlex 2012

plasmablast

(plăz′mə-blăst′)
n.
The precursor or stem cell of a plasma cell.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

plas·ma·blast

(plaz'mă-blast)
Precursor of the plasma cell.
[plasma + G. blastos, germ]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
He described IgG4-RD as "a continuous dance between T cells and B cells." The latest thinking regarding pathogenesis is that type 2 T follicular helper cells activate B cells, which become memory B cells or plasmablasts. These activated B cells and plasmablasts present antigen to CD4+ cytotoxic T cells at sites of disease.
In GLD, plasmablasts may have an Hodgkin morphology and lesions can thus be misdiagnosed as lymphocyte-rich classical Hodgkin lymphoma or nodular lymphocyte predominant Hodgkin lymphoma, especially when germinotropism is not obvious (early forms).
Butcher, "A common mucosal chemokine (mucosae-associated epithelial chemokine/ CCL28) selectively attracts IgA plasmablasts," The Journal of Immunology, vol.
Effect of CR1 Clustering on BCR-Induced Plasmablast Formation and IgM Production.
T-dependent B cell activation leads to the emergence of memory B cells ([B.sub.mem]) as well as plasmablasts 1].
In addition, IgG-positive plasmablasts rapidly decline following treatment with rituximab in patients with IgG4-RD (74).
The investigators demonstrated that AD is accompanied by systemic expansion of transitional and chronically activated memory B cells, plasmablasts, and IgE-expressing memory B cells in both skin and blood.
These studies decoded the global pattern of transcriptional response to TIV vaccination and independently reported that the extent of upregulation of a set of interferon-inducible genes, one to three days after vaccination, and of genes involved in plasmablasts differentiation and activity, seven days after vaccination, correlates with the magnitude of serum functional antibody titers measured after one month.
However, it is suggested that EpsteinBarr virus infection and MYC dysregulation mediated by translocation or amplification [5] could allow plasmablasts to escape apoptosis.
It has to be noted that CD20 is expressed on most types of B-lymphocytes (e.g., pre-B-cells, immature B-cells, naive B-cells, germinal-center B-cells, and memory B-cells) but not on pro-B-cells, plasmablasts, and plasmacells [29].
Aspirates from multiple myeloma show numerous atypical plasmablasts with binucleate and trinucleate atypical plasma cells with high nuclear/cytoplasmic ratio with prominent nucleoli (Figure D).
Numerous mott cells and occasional plasmablasts were also noted (Figure 2).

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