5,6) They share a basis on results of coagulation test results; need for replacement of multiple clotting factors; clinical scenarios in which plasma transfusion is highly likely, such as reversal of warfarin effect and liver disease; and therapy for thrombotic thrombocytopenic purpura and other disorders, often as replacement fluid in plasma exchange therapy
1] In a randomized clinical trail demonstrating the effectiveness of plasma exchange therapy
, the presence of microangiopathichaemolytic anemia and thrombocytopenia without recognized alternative cause was sufficient for the diagnosis of TTP.
However, the patients' clinical condition did not substantially improve despite the 5-day plasma exchange therapy
and viral load only slightly decreased.
The mortality rate of untreated TTP can exceed 90%, but plasma exchange therapy
has reduced that rate to <20%.
She was transferred to a tertiary hospital for plasma exchange therapy
His research helped establish plasma exchange therapy
as a treatment for people with severe MS attacks unresponsive to steroids
During the Phase II study, the Nanobody will be administered to TTP patients as an adjunct to standard plasma exchange therapy
The diagnosis of TTP was made; antiviral medications were discontinued and the patient was admitted for plasma exchange therapy
People with one lesion pattern that includes specific antibodies respond better to plasma exchange therapy
than those with the other three patterns.
MS Lesion Project investigators have published findings showing that people with a specific pattern of tissue damage responded to plasma exchange therapy
while others did not.
Although careful attention should be paid to the microscopic examination of a blood smear in any patient presenting with acute renal failure and thrombocytopenia, the present case and those reported previously emphasize the need to consider TTP and HUS strongly in the differential diagnosis, in view of the overwhelming improvement in morbidity and mortality with plasma exchange therapy
, even in the absence of some of the classic signs of microangiopathic hemolysis.
Call for Expressions of Interest for scientific research grant focused on the efficacy and use of plasma exchange therapy