plasma exchange therapy

plasma exchange therapy

Etymology: Gk, plassein, to mold; L, ex + cambire, to change; Gk, therapeia, treatment
a method of treating certain diseases by removing a part of plasma from the blood supply of a patient and replacing it with plasma from a disease-free person.

plasma exchange therapy

The removal of plasma from a patient (usually to treat an immmunologically mediated illness such as thrombotic thrombocytopenic purpura or myasthenia gravis) and its replacement with normal plasma. Plasma exchange therapy can also be used to replace excessively viscous plasma in patients with Waldenström's macroglobulinemia. Pathological (disease-causing) antibodies, immune complexes, and protein-bound toxins are removed from the plasma by plasma exchange.

Immunoglobulin infusions are an alternative to plasma exchange when treating some immunological illnesses, including Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy.

Synonym: hemapheresis; plasmapheresis
References in periodicals archive ?
5,6) They share a basis on results of coagulation test results; need for replacement of multiple clotting factors; clinical scenarios in which plasma transfusion is highly likely, such as reversal of warfarin effect and liver disease; and therapy for thrombotic thrombocytopenic purpura and other disorders, often as replacement fluid in plasma exchange therapy.
1] In a randomized clinical trail demonstrating the effectiveness of plasma exchange therapy, the presence of microangiopathichaemolytic anemia and thrombocytopenia without recognized alternative cause was sufficient for the diagnosis of TTP.
However, the patients' clinical condition did not substantially improve despite the 5-day plasma exchange therapy and viral load only slightly decreased.
The mortality rate of untreated TTP can exceed 90%, but plasma exchange therapy has reduced that rate to <20%.
She was transferred to a tertiary hospital for plasma exchange therapy.
His research helped establish plasma exchange therapy as a treatment for people with severe MS attacks unresponsive to steroids
During the Phase II study, the Nanobody will be administered to TTP patients as an adjunct to standard plasma exchange therapy.
The diagnosis of TTP was made; antiviral medications were discontinued and the patient was admitted for plasma exchange therapy.
People with one lesion pattern that includes specific antibodies respond better to plasma exchange therapy than those with the other three patterns.
MS Lesion Project investigators have published findings showing that people with a specific pattern of tissue damage responded to plasma exchange therapy while others did not.
Call for Expressions of Interest for scientific research grant focused on the efficacy and use of plasma exchange therapy