plasma exchange therapy

plasma exchange therapy

Etymology: Gk, plassein, to mold; L, ex + cambire, to change; Gk, therapeia, treatment
a method of treating certain diseases by removing a part of plasma from the blood supply of a patient and replacing it with plasma from a disease-free person.

plasma exchange therapy

The removal of plasma from a patient (usually to treat an immmunologically mediated illness such as thrombotic thrombocytopenic purpura or myasthenia gravis) and its replacement with normal plasma. Plasma exchange therapy can also be used to replace excessively viscous plasma in patients with Waldenström's macroglobulinemia. Pathological (disease-causing) antibodies, immune complexes, and protein-bound toxins are removed from the plasma by plasma exchange.

Immunoglobulin infusions are an alternative to plasma exchange when treating some immunological illnesses, including Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy.

Synonym: hemapheresis; plasmapheresis
References in periodicals archive ?
She was transferred to a tertiary hospital for plasma exchange therapy.
His research helped establish plasma exchange therapy as a treatment for people with severe MS attacks unresponsive to steroids
Weinshenker was intrigued when his colleague Moses Rodriguez, MD, found that six people whose attacks did not respond to steroid treatment improved dramatically with plasma exchange therapy.
Luke's Medical Center in Milwaukee report that plasma exchange therapy or PLEX dramatically improves the health of multiple sclerosis patients who fail to respond to conventional therapies.
Patients received weekly plasma exchange treatments for 10 weeks, with the pace of plasma exchange therapy slowing over time or as their condition improved.
MS Lesion Project investigators have published findings showing that people with a specific pattern of tissue damage responded to plasma exchange therapy while others did not.
Lucchinetti and her team looked at the brain tissue samples of 19 people who had been treated with plasma exchange therapy and found that all 10 of the people who had lesion pattern II experienced moderate to substantial improvements following therapy.
Although careful attention should be paid to the microscopic examination of a blood smear in any patient presenting with acute renal failure and thrombocytopenia, the present case and those reported previously emphasize the need to consider TTP and HUS strongly in the differential diagnosis, in view of the overwhelming improvement in morbidity and mortality with plasma exchange therapy, even in the absence of some of the classic signs of microangiopathic hemolysis.
Prompt institution of plasma exchange therapy is critical in management of TTP.
Call for Expressions of Interest for scientific research grant focused on the efficacy and use of plasma exchange therapy
A 17-year old patient with aHUS and history of multiple severe brain ischemic events underwent a third kidney transplant and was started on plasma exchange therapy.
This trial will also assess the safety of ARC1779 in critically ill patients with acute TTP, and it will teach us how to optimize the regimen for administration of ARC1779 in such patients who are undergoing plasma exchange therapy, the current mainstay of treatment for TTP.