plasma cell myeloma


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myeloma

 [mi″ĕ-lo´mah]
1. a tumor composed of plasma cells of the type normally found in the bone marrow.
giant cell myeloma giant cell tumor (def. 1).
multiple myeloma see multiple myeloma.
plasma cell myeloma multiple myeloma.
solitary myeloma a variant of multiple myeloma in which there is a single localized tumor focus. Called also plasma cell tumor.

plas·ma cell my·e·lo·ma

1. Synonym(s): multiple myeloma
2. plasmacytoma of bone, which is usually a solitary lesion and not associated with the occurrence of Bence Jones protein or other disturbances in the metabolism of protein (as observed in multiple myeloma). Some observers emphasize that the solitary lesion probably represents an early phase of classic multiple myeloma, or an example of the latter in which only one focus is recognized.

plas·ma cell my·e·lo·ma

(plazmă sel mīĕ-lōmă)
1. Synonym(s): multiple myeloma.
2. Plasmacytoma of bone, which is usually a solitary lesion and not associated with the occurrence of Bence Jones protein or other disturbances in the metabolism of protein (as observed in multiple myeloma).

plas·ma cell my·e·lo·ma

(plazmă sel mīĕ-lōmă)
1. Synonym(s): multiple myeloma.
2. Plasmacytoma of bone, which is usually a solitary lesion and not associated with the occurrence of Bence Jones protein or other disturbances in the metabolism of protein.

Patient discussion about plasma cell myeloma

Q. Multiple Myeloma what and how is it treated and what is MGUF

A. Were you referring by any chance to MGUS (monoclonal gammopathy of unknown significance)? It's a condition that resembles myeloma but is much more widespread and by itself isn't considered malignant. It may, however, deteriorate to multiple myeloma over the years.

Myeloma is treated with chemotherapy of various kinds, and sometimes with bone marrow transplantation with the patients own bone marrow.

You may read more here:
www.nlm.nih.gov/medlineplus/multiplemyeloma.html

More discussions about plasma cell myeloma
References in periodicals archive ?
Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profiles [published correction appears in Mod Pathol.
(26) Too often, clinicians and pathologists lump "MRD" into one category, although there are clear examples indicating major heterogeneity in testing for specific diseases, as seen in a recent publication on a small survey of MRD testing in plasma cell myeloma. (27)
The reviewers felt it was impossible, given this clinical setting and morphology, to exclude an IgM plasma cell myeloma. Case 3 was a 76-year-old man with 2 monoclonal spikes (IgM [4.6 g/dL] and IgG [1 g/dL]).
Plasma cell myeloma comprises about 1% of malignant tumors, 10-15% of hematopoietic neoplasms (1) and causes 20% of deaths from hematologic malignancies.
A diagnosis of plasma cell myeloma should also be entertained in patients with suspected PEL.
Plasma cell myeloma (PCM) is the most common type of plasma cell neoplasm (PCN), diagnosed in approximately 20 000 patients each year in the United States.
Plasma cell myeloma (PCM) (or multiple myeloma) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) are both common hematologic neoplasms, each constituting about 10% to 11% of all hematologic malignancies.
The plasma cells in LPL have been reported to have a unique immunophenotype, when compared with plasma cells found in marginal-zone lymphoma or plasma cell myeloma, with coexpression of PAX5 and CD45 with CD19, respectively.
(18) Notch1 signaling also appears to play a mechanistic role in the human herpesvirus 8 (HHV-8)-mediated and Jagged1-mediated oncogenesis of PEL and plasma cell myeloma, respectively.
(7) Recognition of these crystals is important to avoid diagnostic confusion with plasma cell myeloma or lymphoplasmacytic lymphoma, which may contain morphologically similar immunoglobulin inclusions.
The patient was diagnosed as having a nonsecretory plasma cell myeloma.
Pathologic Diagnosis: Plasma Cell Myeloma With Multilobated Nuclei

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