Overall, PSRs resulted in a WHO diagnosis in 80 of 85 cases (94%) compared with 54 (64%) for the hematopathology report alone, with increases observed in the cytopenia, MPN,
plasma cell dyscrasia, and lymphoma tracks.
If associated with monoclonal
plasma cell dyscrasia, it is categorized as primary, and when it occurs as a complication of chronic inflammatory diseases, including rheumatoid arthritis, chronic osteomyelitis, or malignancies, it is categorized as secondary.
An SPE is appropriate, however, in an older patient with unexplained anemia, known low immunoglobulin levels, unexplained renal insufficiency or neuropathy, or osteopenia or osteoporosis inconsistent with the patient's age or gender--provided the patient doesn't have a coexisting
plasma cell dyscrasia or B-cell lymphoproliferative disorder, which would throw off the prognostic value of the test results, he continued.
Monoclonal protein evaluation showed elevated IgG level of 5410mg/dL (normal: 700-1600 mg/dL), and bone marrow biopsy demonstrated
plasma cell dyscrasia (plasma cell count of 6%) with no evidence of lymphoproliferative disorder.
Sohani et al., "Bone marrow findings of the newly described TEMPI syndrome: When erythrocytosis and
plasma cell dyscrasia coexist," Modern Pathology, vol.
Her medical history was significant for extranodal marginal zone lymphoma,
plasma cell dyscrasia and amyloidosis diagnosed one year earlier following biopsy of a right cheek mass.
Primary systemic amyloidosis (AL amyloidosis), which is usually associated with an underlying
plasma cell dyscrasia, involves the deposition of insoluble monoclonal immunoglobulin light chains in the skin, muscles, connective tissues, blood vessel walls, peripheral nerves, heart, kidneys, gastro-intestinal tract, and lungs (2).
[7] This uncommon form of
plasma cell dyscrasia is the most aggressive variant of all the monoclonal gammopathies and is defined as >20% plasma cells in peripheral blood or absolute plasma cell count >2x[10.sup.9]/L of the differential count.
Future research should address whether treating the
plasma cell dyscrasia even when these criteria are not met can improve outcomes in the patient with AVWS secondary to a monoclonal protein.
We report five patients with
plasma cell dyscrasia, four had C3GP and one had DDD proven by kidney biopsies.
POEMS syndrome is a underlying
plasma cell dyscrasia related paraneoplastic syndrome and CD is one of the major criteria in the diagnosis of this disease.
What type of
plasma cell dyscrasia is associated with these results?
