plasma cell dyscrasia

plas·ma cell dys·cra·si·a

A diverse group of diseases characterized by the proliferation of a single clone of cells producing a monoclonal immunoglobulin or immunoglobulin fragment (a serum M component). The cells usually have plasma cell morphology, but may have lymphocytic or lymphoplasmacytic morphology. This group includes multiple myeloma, Waldenström macroglobulinemia, the heavy chain disease, benign monoclonal gammopathy, and immunocytic amyloidosis.

plasma cell dyscrasia

A lymphoproliferative disorder characterized by monoclonal proliferation of plasma cells, with clinical behavior ranging from innocuous extramedullary plasmacytomas to premalignant solitary plasmacytoma of bone to myeloma. Cf Monoclonal gammopathy of undetermined significance, Myeloma.
References in periodicals archive ?
Overall, PSRs resulted in a WHO diagnosis in 80 of 85 cases (94%) compared with 54 (64%) for the hematopathology report alone, with increases observed in the cytopenia, MPN, plasma cell dyscrasia, and lymphoma tracks.
If associated with monoclonal plasma cell dyscrasia, it is categorized as primary, and when it occurs as a complication of chronic inflammatory diseases, including rheumatoid arthritis, chronic osteomyelitis, or malignancies, it is categorized as secondary.
An SPE is appropriate, however, in an older patient with unexplained anemia, known low immunoglobulin levels, unexplained renal insufficiency or neuropathy, or osteopenia or osteoporosis inconsistent with the patient's age or gender--provided the patient doesn't have a coexisting plasma cell dyscrasia or B-cell lymphoproliferative disorder, which would throw off the prognostic value of the test results, he continued.
Monoclonal protein evaluation showed elevated IgG level of 5410mg/dL (normal: 700-1600 mg/dL), and bone marrow biopsy demonstrated plasma cell dyscrasia (plasma cell count of 6%) with no evidence of lymphoproliferative disorder.
Sohani et al., "Bone marrow findings of the newly described TEMPI syndrome: When erythrocytosis and plasma cell dyscrasia coexist," Modern Pathology, vol.
Her medical history was significant for extranodal marginal zone lymphoma, plasma cell dyscrasia and amyloidosis diagnosed one year earlier following biopsy of a right cheek mass.
Primary systemic amyloidosis (AL amyloidosis), which is usually associated with an underlying plasma cell dyscrasia, involves the deposition of insoluble monoclonal immunoglobulin light chains in the skin, muscles, connective tissues, blood vessel walls, peripheral nerves, heart, kidneys, gastro-intestinal tract, and lungs (2).
[7] This uncommon form of plasma cell dyscrasia is the most aggressive variant of all the monoclonal gammopathies and is defined as >20% plasma cells in peripheral blood or absolute plasma cell count >2x[10.sup.9]/L of the differential count.
Future research should address whether treating the plasma cell dyscrasia even when these criteria are not met can improve outcomes in the patient with AVWS secondary to a monoclonal protein.
We report five patients with plasma cell dyscrasia, four had C3GP and one had DDD proven by kidney biopsies.
POEMS syndrome is a underlying plasma cell dyscrasia related paraneoplastic syndrome and CD is one of the major criteria in the diagnosis of this disease.
What type of plasma cell dyscrasia is associated with these results?