serum albumin

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Related to plasma albumin: serum albumin, blood albumin

albumin

 [al-bu´min]
1. any protein that is soluble in water and moderately concentrated salt solutions and is coagulable by heat.
2. serum albumin; the most abundant plasma protein, formed principally in the liver and constituting up to two thirds of the 6 to 8 per cent protein concentration in the plasma. (See accompanying table.) Albumin is responsible for much of the colloidal osmotic pressure of the blood, and thus is a very important factor in regulating the exchange of water between the plasma and the interstitial compartment (space between the cells). Because of hydrostatic pressure, water is forced through the walls of the capillaries into the tissue spaces. This flow of water continues until the osmotic pull of protein (albumin) molecules causes it to stop. A drop in the amount of albumin in the plasma leads to an increase in the flow of water from the capillaries into the interstitial compartment. This results in an increase in tissue fluid which, if severe, becomes apparent as edema. Albumin serves also as a transport protein carrying large organic anions, such as fatty acids, bilirubin, and many drugs, and also hormones, such as cortisol and thyroxine, when their specific binding globulins are saturated.

The presence of albumin in the urine (albuminuria) indicates malfunction of the kidney, and may accompany kidney disease or heart failure. A person with severe renal disease may lose as much as 20 to 30 g of plasma proteins in the urine in one day.

A decrease in the serum albumin level may occur with severe disease of the kidney. Other conditions such as liver disease, malnutrition, and extensive burns may result in serious decrease of plasma proteins.
albumin-globulin ratio the ratio of albumin to globulin in blood serum, plasma, or urine.
albumin human a preparation of human serum albumin, used as an artificial plasma extender and to increase bilirubin binding in hyperbilirubinemia.
iodinated I 125 albumin a radiopharmaceutical used in blood and plasma volume, circulation time, and cardiac output determinations, consisting of albumin human labeled with iodine-125.
iodinated I 131 albumin a radiopharmaceutical used in blood pool imaging and plasma volume determinations, consisting of albumin human labeled with iodine-131.
normal human serum albumin albumin human.
serum albumin albumin of the blood.

se·rum al·bu·min

the principal protein in plasma, present in blood plasma and in serous fluids. Participates in fatty acid transport and helps regulate the osmotic pressure of blood. It will also bind hormones, bilirubin, and drugs.

serum albumin

n.
The main serum protein of the blood in humans and other vertebrates, produced in the liver and active in the maintenance of blood osmotic pressure, and in the transport of fatty acids, steroids, and other compounds, including many drugs.

ALB

A gene on chromosome 4q13.3 that encodes albumin, the soluble, monomeric protein that comprises the protein in the serum. It serves as a carrier protein for steroids, fatty acids and thyroid hormones; binds well to water, Ca2+, Na2+, K+, fatty acids, hormones, bilirubin and certain drugs; and plays a central role in stabilising extracellular fluid volume. It is produced in the liver as preproalbumin and partially cleaved before its release from the rough endoplasmic reticulum.

Molecular pathology
ALB mutations cause familial dysalbuminemic hyperthyroxinaemia.

se·rum al·bu·min

(sēr'ŭm al-bū'min)
The principal protein in plasma, present in blood plasma and in serous fluids. Participates in fatty acid transport and helps regulate the osmotic pressure of blood.
Synonym(s): blood albumin, seralbumin.

serum albumin

One of the soluble protein fractions of blood serum. Albumin is important in maintaining the OSMOTIC PRESSURE of the blood.
References in periodicals archive ?
edulis seemed to significantly reduce plasma albumin particularly at the higher C.
Key words: Kampo medicine TJ-15, Oren-gedoku-to, triglyceride plasma level, plasma albumin level, cerebrovascular disease
Plasma albumin, the main contributor to extracellular [A.sub.TOT], decreased on bypass by over 10 g/l (Table 5), whereas the apparent plasma SID reduction with bicarbonate-balanced prime was approximately 5 mEq/l(Table 4).
Some dimerization of albumin is observed with many preparations, including purified plasma albumin (21, 25), but as in previously reported studies, we found albumin dimers to be minor components in urine.
Bromcresol green assay is nonspecific for rat plasma albumin. Am J Physiol.
A single-value correction factor is often used to correct for nonspecific protein interference in Jaffe assays, but this approach does not take into account differences in plasma albumin concentrations among samples.
The mother's plasma albumin was marginally decreased (38 g/L).
The main factor affecting plasma albumin concentration in patients is the rate of transcapillary escape into the interstitial fluid.
Using the equations summarized in Table 1, we calculated bioT at a fixed plasma albumin concentration of 43 g/L.
The remainder of plasma 25[OHD.sub.3] is bound mainly to plasma albumin, which in our study can be ignored because this smaller fraction is almost constant.
Plasma albumin was removed with a convenient Montage Albumin Depletion Kit according to the manufacturer's instructions (Millipore Corporation).