plaque rupture


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plaque rupture

The separation of a lipid-rich lesion from the wall of a blood vessel. The damage this does to the lining of a blood vessel triggers a cascade of events that result in blood clot formation within the vessel and its eventual obstruction. This is the immediate cause of acute myocardial infarction. Synonym: cap rupture
See also: rupture
References in periodicals archive ?
the biomarker could be associated with the risk of flow-limiting thrombus formation once a plaque rupture has occurred).
The designation of AMI is no longer restricted to individuals with acute coronary plaque rupture causing a decreased oxygen supply (type I).
The sudden and unexpected passing of Tim Russert, host of NBC's Meet the Press, is thought to have been the result of a vulnerable plaque rupture.
The study hypothesis was that inhibition of joint inflammation using anti-TNF agents might reduce the inflammation that triggers atherosclerotic plaque rupture and acute coronary and cerebrovascular events, he continued.
Plaque rupture is often associated with the breakdown of ECM in the shoulder region of a plaque (4,5).
1) When there is also high circumferential stress at the luminal border of the plaque, plaque rupture is more likely to occur.
As many as 50 percent of acute coronary syndromes and myocardial infarction may be due to plaque rupture and thrombosis.
Inflammation increases the risk of the plaque rupture in the arteries, but the underlying mechanisms for inflammation are not clear.
And this inflammation is a key factor in plaque rupture, said Dr.
The definitive reasons for plaque rupture are unknown, but inflammation appears to play a major role (2).
The novel test that BG Medicine expects to develop aims to use the biomarker discovered by CARIM to identify plaque rupture in patients early, for instance, when the blockage is temporary or not complete and has not yet caused the common signs and symptoms of heart attack or stroke.