The natural compound Centella asiatica stabilizes the hard, thick cap on atherosclerotic plaques, which slashes the risk of a plaque rupture
In equivocal, difficult cases with acute myocardial injury, in which the clinical distinction between myocardial injury, T1MI, and T2MI is challenging, further diagnostic efforts may be considered in an appropriate clinical context to discern the underlying mechanism, primarily due to the potential therapeutic implications if deemed related to atherosclerotic plaque rupture
Boyle, "Macrophage activation in atherosclerosis: pathogenesis and pharmacology of plaque rupture
," Current Vascular Pharmacology, vol.
This process is accentuated by intra-plaque hemorrhage and plaque rupture
with resultant thrombus formation.
If other aspects of vulnerable blood are present, such as high platelet reactivity, high blood viscosity, or others, there may be sufficient dysfunction present to result in acute thrombosis even without acute plaque rupture
Microcalcifications increase coronary vulnerable plaque rupture
potential: a patient-based micro-CT fluid-structure interaction study.
Because during acute presentation of symptoms, there is a more contemporary continuum of events that begin with plaque rupture
or erosion that lead to UA, and may progress to non-Q wave and Q-wave AMI at any moment .
In our case, probably, he has had early onset coronary heart disease in whom the cigarette smoking was the single risk factor and cannabis smoking triggered the plaque rupture
and induced thrombosis.
Unstable angina or heart attack can be the result of such plaque rupture
The level of the enzyme in the bloodstream is related to the progression of instability of the atherosclerotic plaque, and the likelihood for plaque rupture
and a resulting thrombotic event.
Among the topics are plaque rupture
models in mice, detecting and quantifying apoptosis in the vasculature, evaluating endothelial function in in-vivo microscopy, assessing protein glocoxidation in ventricular tissues, and stem cell therapy in the heart and vasculature.
Dr Cressida Lyon, from the Bristol Heart Institute, said: "This study is the first demonstration that reduction of cell death with soluble N-cadherin can reduce the likelihood of plaque rupture