PKP1

(redirected from plakophilin 1)

PKP1

A gene on chromosome 1q32 that encodes plakophilin 1, which is thought to play a role in junctional plaques and contribute to epidermal morphogenesis.

Molecular pathology
Defects in PKP1 cause ectodermal dysplasia-skin fragility syndrome.
References in periodicals archive ?
Hatzfeld, "Plakophilin 1 stimulates translation by promoting eIF4A1 activity," The Journal of Cell Biology, vol.
Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability.