Plakophilin 1 | definition of plakophilin 1 by Medical dictionary
PKP1 (redirected from plakophilin 1)
PKP1 A gene on chromosome 1q32 that encodes plakophilin 1, which is thought to play a role in junctional plaques and contribute to epidermal morphogenesis.
Defects in PKP1 cause ectodermal dysplasia-skin fragility syndrome.
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References in periodicals archive
Structure of the armadillo repeat domain of plakophilin 1
Hatzfeld, "Plakophilin 1
stimulates translation by promoting eIF4A1 activity," The Journal of Cell Biology, vol.
Lack of plakophilin 1
increases keratinocyte migration and reduces desmosome stability.