VE-cadherin and the armadillo family protein plakoglobin
regulate vascular endothelial permeability and growth.
Naxos syndrome is correlated with a homozygous deletion of two base pairs found in the plakoglobin
gene located in the 17q21.2 locus (Table 1) [11, 23].
Ben-Zeev, "Differential mechanisms of LEF/TCF family-dependent transcriptional activation by [beta]-catenin and plakoglobin
," Molecular and Cellular Biology, vol.
Usefulness of immunostaining for plakoglobin
as a diagnostic marker of arrhythmogenic right ventricular cardiomyopathy.
, desmoplakin and desmocollin-2 are family members of desmosomal proteins that function as cell-cell adhesion junction, and are expressed in skin, heart and hair.5
The probable molecular mechanism hypothesized was that by mutating desmosomal protein impairs desmosomal assembly releasing free plakoglobin
from the desmosomes, which could translocate into the nucleus and through competition with [beta]-catenin suppress signaling through the canonical Wnt/ [beta]-catenin-Tcf/Lef pathway.
and [beta]-catenin: distinct but closely related.
Whereas the cadherins in most AJs are linked to the actin cytoskeleton through [alpha]-and [beta]-catenin, desmosomal cadherins recruit the armadillo proteins plakoglobin
and plakophilin-1, which are vertebrate-specific gene duplications related to [beta]-catenin and are linked to the intermediate filament cytoskeleton either directly or via the linker protein desmoplakin (Schneider et al., 2003).
Gumbiner, "A homolog of the armadillo protein in Drosophila (plakoglobin
) associated with E-cadherin," Science, vol.
Differential nuclear translocation and transactivation potential of beta-catenin and plakoglobin
. J Cell Biol.
In mouse models, knockdown of plakoglobin
abrogates CTC cluster formation and suppresses lung metastases (18).
They went on to demonstrate that overexpression of DSP led to increased plakoglobin