A class of intermediate filament-binding proteins that act in linking keratin filaments to hemidesmosomes in epithelial cells as well as neurofilaments to actin in neurons. Moreover, in many cells they also find intermediate filaments, actin, and microtubules to each other, assisting in the formation of a three-dimensional lattice of cytoskeletal elements.
See also: hemidesmosomes, cytoskeleton.
[G. plakoō, to cover with plates, + -in]
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Those that are towards plakins are a characteristic feature (24).
However, autoantibodies against various targets can be found, including desmosomal proteins Dsg1 and Dsg3, plakin family proteins (periplakin, envoplakin, plectin, desmoplakin, and BP180), and the protease inhibitor alpha-2-macroglobulin-like antigen 1 (A2ML1) (3, 20, 23).
Adhesion between corneocytes is assumed to occur by the desmosome apparatus (corneodesmosome), composed of desmosomal cadherin, armadillo proteins, and plakins. The CE, intercellular lipid lamellae, and corneodesmosome are essential for effective physical and water barrier functions in the epidermis.
Other molecules studied by [150] are plakins, which represent a family of molecules which form the links between filaments, desmosomes, and hemidesmosomes and plectin is a cytolinker of this family.
Thornton, Tamara Plakins. Handwriting in America: A Cultural History.
Further, Tamara Plakins Thornton in Handwriting in America: A Cultural History (1996, p.
Kurosawa et al., "Longitudinal analysis of antibody profiles against plakins in severe drug eruptions: emphasis on correlation with tissue damage in drug-induced hypersensitivity syndrome and drug reaction with eosinophilia and systemic symptoms," British Journal of Dermatology, vol.