human placental lactogen

(redirected from placental growth hormone)

lactogen

 [lak´to-jen]
any substance that enhances lactation.
human placental lactogen (HPL) (hPL) a hormone secreted by the placenta, which disappears from the blood immediately after delivery. It has lactogenic, luteotropic, and growth-promoting activity, and inhibits maternal insulin activity during pregnancy.

hu·man pla·cen·tal lac·to·gen (HPL),

lactogen isolated from human placentas and structurally similar to somatotropin; its biologic activity weakly mimics that of somatotropin and prolactin; secreted into maternal circulation; a deficiency of HPL during pregnancy leads to children who undergo abnormal intrauterine and postnatal growth.

human placental lactogen (HPL)

a placental hormone that may be deficient in certain abnormalities of pregnancy. The normal concentrations of this hormone in serum after the fifth week of pregnancy are 0.5 μg/mL and increase to approximately 8 μg/mL at the time of delivery. Also called chorionic somatomammotropin.

human placental lactogen

Chorionic somatomammotropin, hPL, human placental lactogen, human chorionic somatomammotropin A hormone produced during implantation of a fertilized egg, and secreted by the placenta; hPL regulates and coordinates fetal growth and metabolism and maternal metabolism Maternal effects Relative insulin resistance, ↑ circulating free fatty acids; hPL may optimize metabolism of nutrients by the fetus in 1st half of pregnancy; in 2nd half, there is little correlation between hPL levels and fetal well-being; hPL stimulates milk production and breast enlargement, and is somatotopic and luteotropic; urine and plasma HPL levels reflect placental size and are higher in diabetic mothers Ref range Rises during gestation, plateauing at 37 wks at 10 mg/mL; ♂ <0.5 mg/mL; non-pregnant ♀ <0.5 mg/mL; wks of gestation 5-27 <4.6 mg/mL; 28-31 wks, 2.4-6.1 mg/mL; 32-35 wks, 3.7-7.7 mg/mL; 36 wks to term, 5-8.6 mg/mL; hPL is ↓ in postmaturity syndrome, retarded growth, toxemia of pregnancy, threatened abortion; it is ↑ DM, Rh isoimmunization, hydatiform mole, choriocarcinoma Critical value <4 μg/mL after 30 wks gestation

hu·man pla·cen·tal lac·to·gen

(hyū'măn plă-sen'tăl lak'tŏ-jen)
Any agent to stimulate human milk production that has been isolated from human placentas; its biologic activity mimics that of somatotropin and prolactin; secreted into maternal circulation; deficiency during pregnancy leads to abnormal intrauterine and postnatal growth.
Compare: bioregulator
Synonym(s): chorionic growth hormone-prolactin, human chorionic somatomammotropic hormone, placental growth hormone.
References in periodicals archive ?
Some researchers suggest that the PR occur due to aggravation of subclinical allergy5,6 while majority claim the rising serum levels of hormones like progesterone, estrogen and placental growth hormone.
Estrogen, progesterone, human chorionic gonad-otropin hormone (HCG), human placental lactogen (HPL) and placental growth hormone (PGH) whose levels are known to be gradually rise throughout the pregnancy have been evaluated in different studies for a possible association with PR.
Gruslin and others suggests that IGFBP-4 blocks the activity of a key placental growth hormone called IGF-II, which results in poor growth of the placenta and fetus.