Accuracy of circulating placental growth factor
, vascular endothelial growth factor, soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia: a systematic review and meta-analysis.
Longitudinal serum concentrations of placental growth factor
: Evidence for abnormal placental angiogenesis in pathologic pregnancies.
* Considered maternal characteristics: African-American ethnicity, body mass index, pregestational diabetes mellitus; ** Considered maternal characteristics: African-American ethnicity, body mass index, systolic blood pressure, and educational level; PAPP-A, pregnancy-associated plasma protein A; ADAM-12, A Disintegrin and Metalloprotease 12; PlGF, placental growth factor
; sFlt-1, soluble fms-like tyrosine kinase 1; PP13, placental protein 13; AUC, area under the curve.
 Nonstandard abbreviations: sFlt1, soluble fms-like tyrosine kinase 1; PIGF, placental growth factor
These antiangiogenic factors are induced or exacerbated by placental ischaemia, with sFlt1 being a circulating antagonist to both vascular endothelial growth factor (VEGF) and placental growth factor
. Circulating VEGF is mopped up by sFlt1to prevent the former's protective effects on the endothelium.
Independentemente do modelo proposto como causa da pre-eclampsia, sabe-se que na gestacao normal existe uma interacao do trofoblasto endovascular e dos leucocitos deciduais, especialmente celulas natural-killer, resultando na liberacao de mitogenos responsaveis pela angiogenese necessaria para o desenvolvimento placentario, principalmente o fator de crescimento endotelial vascular (VEGF, do ingles vascular endotelial growth factor) e o fator de crescimento placentario (PIGF, do ingles placental growth factor
Palm M Basu S Larsson A Wernroth L Akerud H Axelsson O.A longitudinal study of plasma levels of soluble fms-like tyrosinekinase 1 (sFlt1) placental growth factor
(PlGF) sFlt1: PlGF ratioand vascular endothelial growth factor (VEGF-A) in normalpregnancy.
Wolf et al., "First trimester placental growth factor
and soluble fms-like tyrosine kinase 1 and risk for preeclampsia," Journal of Clinical Endocrinology and Metabolism, vol.
Chronic ischemia caused by poor vascularization is associated with the placental production of angiogenic factors like vascular endothelial growth factor (VEGF), placental growth factor
(PlGF), and soluble fms-like tyrosine kinase-1 (sFlt-1).
Presented at the 18th World Congress on Controversies in Obstetrics, Gynecology & Infertility (COGI) held in Vienna in October, the study is investigating the correlation between the ratio of two proteins sFlt-1 (soluble fms-like tyrosine kinase-1) and PlGF (placental growth factor
) in maternal blood and the risk of developing preeclampsia over the subsequent four weeks.
The test works by measuring a particular placental growth factor
. The level of PIGF in a mother's blood is an important marker for you and your baby's wellbeing.
Aflibercept is a fully human fusion protein that binds all forms of VEGF-A, as well as VEGF-B and placental growth factor