placental alkaline phosphatase


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia.
Related to placental alkaline phosphatase: Leukocyte alkaline phosphatase

placental alkaline phosphatase

Abbreviation: PLAP
A form of heat-stable alkaline phosphatase released by trophoblast cells in the human placenta, i.e. during pregnancy. Cancers of colon, lung, ovary, and testes, esp. seminoma, produce the enzyme ectopically.
See also: phosphatase
Mentioned in ?
References in periodicals archive ?
Manivel JC, Jessurun J, Placental alkaline phosphatase immunoreactivity in testicular germ-cell neoplasms.
In addition, germ cell tumors are often positive for placental alkaline phosphatase while most Sertoli-Leydig cell tumors are positive for pancytokeratins.
Maternal blood placental alkaline phosphatase (PAP) activity was assayed by the Thymolphthalein Monophosphate method (4) using the maternal sera samples heated at 65[degrees]C for 7 min.
The placental alkaline phosphatase (Dako, Santa Barbara, Calif) showed strong specific membrane staining of the larger necrotic cells, definitively identifying them as seminoma cells (Figure 3).
Enzyme amplification--a general method applied to provide an immunoassisted assay for placental alkaline phosphatase.
The antibodies used were specific for CD45RB (leukocyte common antigen; 1:300, Dako Corporation, Carpinteria, Calif), CD3 (1:150, Dako), CD20 (L26; 1:700, Dako), CD79a (1:50, Dako), [Kappa] immunoglobulin light chain (1:10000, Dako), [Lambda] immunoglobulin light chain (1:10000, Dako), Bcl-6 (1: 10, Dako), epithelial membrane antigen (1:25, Dako), CD10 (1:70, Vector, Burlingame, Calif), CD30 (1:20, Signet, Dedham, Mass), Bcl-2 (1:200, BioGenex, San Ramon, Calif), Ki-67 (1:20, Beckmann Coulter, Miami, Fla), keratin (AE1/AE3; 1:500, Boehringer Mannheim, Indianapolis, Ind), [Alpha]-fetoprotein (1:25, Zymed Lab, San Francisco, Calif), and placental alkaline phosphatase (1:20, Lab Vision Corp, Freemont, Calif).