placental alkaline phosphatase


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Related to placental alkaline phosphatase: Leukocyte alkaline phosphatase

placental alkaline phosphatase

Abbreviation: PLAP
A form of heat-stable alkaline phosphatase released by trophoblast cells in the human placenta, i.e. during pregnancy. Cancers of colon, lung, ovary, and testes, esp. seminoma, produce the enzyme ectopically.
See also: phosphatase
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References in periodicals archive ?
In addition, germ cell tumors are often positive for placental alkaline phosphatase while most Sertoli-Leydig cell tumors are positive for pancytokeratins.
Maternal blood placental alkaline phosphatase (PAP) activity was assayed by the Thymolphthalein Monophosphate method (4) using the maternal sera samples heated at 65[degrees]C for 7 min.
In contrast, nonseminomatous tumors, independent of the histology and the cell lines derived from them, have lost their VASA expression.14 Placental alkaline phosphatase has been observed in isolated or small groups of tumor cells.
Additional serologic testing revealed that the patient's alpha-fetoprotein (AFP), human placental alkaline phosphatase, prostate-specific antigen, carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9), and thyroglobulin levels were within normal limits.
Molecular cloning and sequence analysis of human placental alkaline phosphatase. J Biol Chem 1986;261:3112-5.
To confirm this impression, immunohistochemical stains for placental alkaline phosphatase, leukocyte common antigen (LCA), and keratin were performed.