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A gene on chromosome 19p13.3 that encodes a ubiquitously expressed serine/threonine-protein kinase which controls the activity of AMP-activated protein kinase (AMPK) family members, playing a role in various cellular processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. STK11 acts by phosphorylating the T-loop of AMPK family proteins, upregulating their activity.

Molecular pathology
Defects in STK11 are a cause of Peutz-Jeghers syndrome; it has been linked to testicular germ cell tumours and sporadically to non-small cell carcinomas of the lung. Defects in STK11 also promote carcinogenesis, including lung cancer progression and metastasis, and confers in lung adenocarcinoma the ability to trans-differentiate into squamous cell carcinoma.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Abbreviation for Peutz-Jeghers syndrome.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Reports said that PJ and Jehza were supposed to tie the knot last year, but it was rescheduled because PJ's team advanced in the PBA Finals' Governors' Cup.
'Until PJ's TOD guidelines are accepted with sincere public participation, it has to be put on hold,' he said.
PJ's will operate as a Pep Boys service and tire centre, offering total car care to customers.
"PJ's Coffee exudes quality," said Rick Yvanovich, who represents TRG International.
In April, Chelsea and WPF cofounder Amanda Chadwick received a Points of Light Award (given to outstanding and inspirational volunteers), and the work the charity does has been brought into the spotlight with recent television appearances and coverage, including when a WP Fairy made a pair of matching pj's for four year old Harry Maceachen and his dad Simon, prior to Harry receiving part of his father's liver in a groundbreaking transplant operation.
PJ's indefatigability likely stemmed from the fact that he'd never been handed anything in his life.
That's harder than imagined given PJ's eccentric nature.
Ketchup has recruited executive chef Jorge Da Silva, who brings to Ketchup over 15 years of experience working in some of London's establishments including PJ's Bar and Grill, Maxwells, Cactus Blue and The Farm.
The 25-dollar Smart PJ's, which are available in pink and blue, have 47 colorful dot patterns that work with an app.
The next month found us working in our pj's yet again, this time as NASA's Curiosity rover executed a spectacular touchdown on Mars in the early a.m.
PJ's grandfather served in the war and liberated Goering's hideout so could have taken the Monet home, he argues.
"PJ's main concern was always his rent and council tax," explained Annette.