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A gene on chromosome 19p13.3 that encodes a ubiquitously expressed serine/threonine-protein kinase which controls the activity of AMP-activated protein kinase (AMPK) family members, playing a role in various cellular processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. STK11 acts by phosphorylating the T-loop of AMPK family proteins, upregulating their activity.

Molecular pathology
Defects in STK11 are a cause of Peutz-Jeghers syndrome; it has been linked to testicular germ cell tumours and sporadically to non-small cell carcinomas of the lung. Defects in STK11 also promote carcinogenesis, including lung cancer progression and metastasis, and confers in lung adenocarcinoma the ability to trans-differentiate into squamous cell carcinoma.


Abbreviation for Peutz-Jeghers syndrome.
References in periodicals archive ?
With spring setting in, and summer around the corner, we are excited to launch our new tea mixers -- a refreshing change of pace for a hot day," says Reid Nolte, Director of Marketing & Brand Strategy for PJ's Coffee.
To meet their clients at home needs, PJ's Coffee recently launched a cold brew concentrate at their PJ's locations.
The setting for the commercial is inside PJ's Pub and Grill event space.
Over two decades, PJ's mum Maureen, 53, and Gary's mum Grace, also 53, reached out to thousands of kids.
Yee-yee," is one of PJ's trademark expressions, and it came from one of his hand-puppets he used in the band.
The PJ's emphasis on the role of courts as protectors of the individual and his unique empathy, illustrated so vividly in his dissents, are also on display in what the PJ considers one of his signature decisions, Matter of Matthews.
Deep appreciation goes to PJ's brothers, Billy and Jack, and to his widow Jo's family, who supported her through PJ's illness.
PJ's is so admired for its sales and support of European wines, in fact, that owner Peter Yi became in 2006 one of the few retail recipients of the European Wine Council's annual Wine Ambassador award, given in recognition of his work passionately promoting and selling wines from participating countries.
A spokeswoman said: "Police were called to PJ's hotel and pub on Station Road in Percy Main following reports that a theft had been carried out overnight and a quantity of cash had been stolen.
Of course, how the retailers react to PJ's going head to head with their own brands will also have a bearing.
PJ's reaction time that day probably saved her life; definitely the most inspiring thing any of us saw on the trip.
In the four years since PJ's last studio effort, tastes and formats have evolved.