and some narrow clefts were randomly distributed within the nerve fibre bundles.
This degree of sharp circumscription between normal compressed gland and adenoma is most often seen in macroadenomas; on microadenomas, normal pituicytes
may be admixed with adenoma cells at the edges of the adenoma.
In the NL, the structural plasticity is accompanied by a reorganisation of magnocellular terminals and adjacent pituicytes. These cells generally surround or enclose the terminals of MCN under basal conditions.
Its localisation is in pituicytes processes and may be in endothelial cells, might enhance the access of neuropeptides to blood stream by improving cell shape, as shown for vimentin in immature glia during development .
A neurohypophyseal tumor originating from pituicytes
. Am J Clin Pathol.
Nonneoplastic pituicytes are reported to be positive with GFAP[7-9]; however, the staining patterns with the antibody have not been well characterized.
As the name suggests, pituicytomas most likely derive from pituicytes, the specialized glial population of the normal' posterior lobe.
In conclusion, pituicytomas are a rare and unique type of glioma derived from pituicytes and distinct from other intrasellar neoplasms, including granular cell tumors and pilocytic astrocytomas.
Immunoreactive glial fibrillary acidic protein in pituicytes of the rat neurohypophysis.
Identification of the pituicytes as astroglial cells by indirect immunofluorescence-staining for the glial fibrillary acidic protein.
Tumor cells are negative for anterior pituitary hormones, keratin, vimentin, desmin, and neuron-specific enolase. Although glial fibrillary acidic protein is typically reported as negative in GCTs of the infundibulum, glial fibrillary acidic protein has been demonstrated in tumor cells by electron immunocytochemistry. It is suggested that GCTs and their tumorlet precursors derive from pituicytes
and thus are astrocytic in nature and therefore a form of glioma.[4,5,6,9] The relationship, however, between the histogenesis of GCT and pituicytoma, a distinctive low-grade glioma of the neurohypophysis, remains controversial. Approximately one third of GCTs coexist with pituitary adenomas, and common precursor cells for tumorigenesis have been suggested.