Unfortunately, some pharmacological treatments such as Olanzapine for the treatment of psychosis cause secondary side effects such as severe drowsiness (1), and furthermore, other PD drugs such as Piribedil
, Pramipexole, and Ropiniole only modestly or negligibly improve motor impairments (13).
Parkinsonian apathy responds to dopaminergic stimulation of D2/D3 receptors with piribedil
Millan, "From the cell to the clinic: a comparative review of the partial [D.sub.2]/[D.sub.3] receptor agonist and [[alpha].sub.2]-adrenoceptor antagonist, piribedil
, in the treatment of Parkinson's disease," Pharmacology & Therapeutics, vol.
Klinger et al., "Parkinsonian apathy responds to dopaminergic stimulation of D2/D3 receptors with piribedil
," Brain, vol.
Persons who used only piribedil
, amantadine, or anticholinergic agents (i.e., drugs rarely used for PD) were first contacted by mail; they were asked why these drugs had been prescribed, and those who answered PD/parkinsonism or did not know were invited to be examined by a neurologist.
Medications were converted into an equivalent dose of immediate-release levodopa (Madopar, Roche, Basel, Switzerland), according to the following formula: 100 mg immediate-release levodopa = 133 mg controlled-release levodopa = 1 mg pramipexole = 100 mg piribedil
= 10 mg selegiline; each dose of levodopa was 25% more effective with entacapone.
Eighteen patients (in stage 2.5-4) were treated with Levodopa in combination with another symptomatic treatment (dopamine agonists, MAO--B inhibitors, COMT inhibitors and piribedil
Bismuth(III)-iodide compounds have been used as reagents for determination of some nitrogenous drugs such as amineptine hydrochloride, piribedil
, and trimebutine maleate .
Dopaminergic insufficiency reflecting cerebral ageing: value of a dopaminergic agonist, piribedil
. Journal of Neurology, 239 (Suppl.