pirenzepine


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pirenzepine

A drug formerly used to cut secretion of acid by the stomach in the treatment of PEPTIC ULCER but now discontinued.

pirenzepine

a selective M1 cholinergic antagonist; used as an antiemetic in dogs.
References in periodicals archive ?
Pirenzepine is also an anti-muscarinic drug that is routinely used in the treatment of gastric ulcers.
2] muscarinic receptors by pirenzepine or methoctramine, respectively, worsen Fade (50 Hz) induced by cisatracurium when this neuromuscular relaxant causes 17% Fade (50 Hz) (Pereira et al.
Atropine, pirenzepine dihydrochloride, N,N-dimethyl sulfoxide (DMSO), 2,3,5-triphenyltetrazolium chloride solution (TTC), 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide (MTT), and L-glutamic acid monosodium salt were purchased from Sigma (St.
3], was suggested to be present in smooth muscles, and characterized by low affinity for pirenzepine and high affinity for 4-DAMP (4-diphenylacetoxy-N-methylpiperidine methiodide), for which the [M.
Using the M1 receptor antagonist pirenzepine (PIR), the M3 receptor antagonist 4-diphenyl-acetoxy-N-methyl-piperidine methiodide (4-DAMP), and the cholinergic agonist carbachol, here we investigated the potential role of Ml and M3 mAChRs in mLTD induction and in increasing phosphorylated ERK levels in juvenile and adults rats.
Antimuscarinic medications such as benztropine, trihexyphenidyl, amitriptyline, or pirenzepine often are used to reduce hypersalivation, (6) although 1 systematic review concluded further evidence is needed to support the effectiveness of this approach.
When investigators gave pirenzepine 25-100 mg/day to 120 patients with drooling because of clozapine, improvement was noted (Lancet 1995;346:1034).
The selective muscarinic cholinergic receptor antagonists used were: pirenzepine (Ml receptor; 10 and 100 nM); methoctramine (M2 receptor; 1 and 10 AM); N-(2-chloroethyl)-4-piperidinyl diphenylacetate N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP; M3 receptor; 10 and 100 nM); and tropicamide (M4 receptor, 1 and 10 [micro]M).
Comparison of pirenzepine, ranitidine, and pirenzepine-ranitidine combination for reducing preoperative gastric fluid acidity and volume in children.
Numerous anticholinergic medications, including glycopyrolate, scopolamine propantheline bromide, and pirenzepine, have been used in humans with varying results.
All patients were also given 150 mg pirenzepine to reduce gastric acid secretion, and also given antiemetics as needed; they were admitted to the hospital for at least 1 day.
An antimuscarinic like atropine, pirenzepine causes minimal mydriasis and cycloplegia.