In our study, Colistin and Polymyxin-B antibiotics had 100% sensitivity followed by carbapenems (86%), Amikacin (74.4%), Moxifloxacin (69.8%), levofloxacin (62.8%), Ciprofloxacin (62.8%), Piperacillin-tazobactam
(62.8%) and the least was in Azithromycin (32.6%).
cefoperzone-sulbactam and piperacillin-tazobactam
, having almost 70% susceptibility followed by aminoglycosides and carbapenems having more than 60% of susceptibility; similar observations were reported by Kombade et al 23.
Antimicrobial susceptibility testing revealed that none of the Gram-negative bacteria found to be resistant to amikacin, cefoperazone-sulbactam and piperacillin-tazobactam
. Some of the isolates exhibited resistance to carbapenems, and other antibiotics have shown in the Table-III.
One study noted that the resistant pattern of AmpC b-lactamases to piperacillin-tazobactam
(36.73%), amikacin (73.46%), ciprofloxacin (53.06%) and gentamicin (69.38%).
Drew, "Comparison of the incidence of vancomycin-induced nephrotoxicity in hospitalized patients with and without concomitant piperacillin-tazobactam
," Pharmacotherapy, vol.
Unfortunately, her aspirate was not sent for cell counts but was appropriately placed on piperacillin-tazobactam
given her risk for atypical and gram-negative organisms.
Based on the [MIC.sub.50] value, ceftolozane-tazobactam was 2-fold more active than meropenem ([MIC.sub.50], 1[micro]g/mL), 8-fold more active than cefepime ([MIC.sub.50], 4[micro]g/mL) and ceftazidime ([MIC.sub.50], 4[microg/mL), and 16-fold more active than piperacillin-tazobactam
([MIC.sub.50], 8 [micro]g/mL) (Table 2).
Overall success was observed in 183/186 patients (98.4%) in the meropenem-vaborbactam group and in 165/175 patients (94.3%) in the piperacillin-tazobactam
group a difference of 4.1% (95% CI: 0.3% to 8.8%).
We conducted a 6-month retrospective record review to determine whether there is bacterial culture data to support our initial empiric gram-negative double coverage with extended antipseudomonal beta-lactam (piperacillin-tazobactam
) and fluoroquinolones (ciprofloxacin and levofloxacin) in our military hospital patient population.
Argentinean collaborative multicenter study on the in vitro comparative activity of piperacillin-tazobactam
against selected bacterial isolates recovered from hospitalized patients.
In our study, members of Enterobacteriaceae family showed high sensitivity to imipenem followed by amikacin and piperacillin-tazobactam
. This is similar to sensitivity reported by Mahamood.
(2) Our patient showed resistance to carbapenems and piperacillin-tazobactam
. This finding suggests the emergence of carbapenem-resistant P .putida, and gives the alarming signal for the future, making the therapeutic options more difficult especially in empirically treating post-neurosurgical meningitis.