The company cited a study as showing that lack of piperacillin
could result in more than 2,000 additional deaths per year from serious infections in Europe as doctors resort to less effective alternatives.
was suspected as the causative agent of the mucosal skin reaction of the patient.
coli isolates, the sensitivity pattern towards, Cefepime Tazobactam was 90%, Cefepime 32%, Piperacillin
Tazobactam -75%, Cefoperazone sulbactam -71%, Carbapenem- 91%, and Amikacin- 92%.
pneumoniae isolates were resistant to cephalosporins, trimethoprim/sulfamethoxazole, aztreonam, piperacillin
, and piperacillin/tazobactam.
sodium has been successfully used in avian medicine for many years because of its broad spectrum antibacterial properties, (2) piperacillin
sodium/tazobactam sodium injectable (Zosyn, Wyeth, Philadelphia, PA, USA) was approved by the Food and Drug Administration in 1994 and is actually a superior product to piperacillin
alone because of the addition of the [beta]-lactamase inhibitor tazobactam.
Among them, predominant organisms were Gram-negative bacilli with Pseudomonas (18 isolates) being most common organism with the highest sensitivity to piperacillin
+ tazobactam, imipenem and amikacin.
For bacteria isolated from diabetic foot infection, the following antibiotics were used against the causative agents: amikacin (30ug), (20ug of amoxicillin + 10ug of clavulanate), cefotaxime (30ug), ceftazidime (30ug), ciprofloxacin (5ug), erythromycin (15ug), gentamycin (10ug), oxacillin (1ug), piperacillin
(100ug) and vancomycin (30ug).
In the recurrent Paeruginosa group, the antimicrobial sensitivity test showed low resistance (ratio of resistance <20%) to carbapenems (imipenem and meropenem), extended-spectrum [beta]-lactams (aztreonam, piperacillin
, and piperacillin/tazobactam), and polymyxin, but higher resistance (ratio of resistance >80%) to sulfonamides (trimethoprim/ sulfamethoxazole) and tetracyclines (minocycline).
Resistance pattern of all the isolates when analysed as a group against various classes of antibiotics showed that the isolates exhibited high resistance to Piperacillin
and Cotrimoxazole while, the resistance against ceftazidime and cefipime was >40%.
The organism is highly resistant to Azithromycin (77.78%), Ciprofloxacin (55.56%), Gatifloxacin (44.44%) and Piperacillin
(55.56%) (Table 1 and Fig.
Resistance rates to all antibiotics routinely tested across each genus Antibiotic % resistance Antibiotic % resistance Amikacin 8 Colistin 12 Ampicillin 85 Ertapenem 2 Co-amoxiclav 49 Erythromycin 53 Benzyl penicillin 100 Gentamicin 35 Cefotaxime 49 Imipenem 23 Cefoxitin 49 Linezolid 0 Ceftazidime 44 Meropenem 19 Cephamdole 84 Piperacillin
21 -tazobactam Ciprofloxacin 30 Trimethoprim 77 Cloxacillin 22 Vancomycin 10 Table 6.
Staphylococcus aureus showed highest susceptibility to imipenem (90%) piperacillin
/ tazobactam (70%) clavulanic acid (67%) cloxacillin (61%) amikacin and doxycycline (59%) sulbactam /###cefoperazone###(57%)###and###clindamycin###(51%) while it demonstrated highly resistant pattern to chloramphenicol (88%) erythromycin (82%) fusidic acid (76%) fosfomycin and clarithromycin