pipecolic acid

pip·e·co·lic ac·id

(pip'ĕ-kō'lik as'id),
Dihydrobaikiaine; 2-piperidinecarboxylic acid; saturated picolinic acid; the l-isomers of the Δ1- and Δ6-dehydropipecolic acids are intermediates in the catabolism of l-lysine; pipecolic acid accumulates in disorders of the peroxisomes.
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When antiquitin activity reduces, pipecolic acid, AASA ve 1-piperidin-6- carboxyilate accumulate.
P6C is also known to be an intermediate in the pipecolic acid pathway and its accumulation leads to enzymatic block which in turn results in toxic levels of pipecolic acid [5].
Compared with BP group, 23 metabolites were significantly altered in SD group: creatinine, azelaic acid, protocatechuic acid, and 3,4-dihydroxyhydrocinnamic acid were upregulated, yet lactate, glycolic acid, alanine, nicotinic acid, phenylacetic acid, glycine, 4-deoxyerythronic acid, pipecolic acid, 2,4-dihydroxybutanoic acid, nicotinamide, uracil, threonic acid, suberic acid, putrescine, citric acid, hippurate, lysine, urate, and ascorbic acid were downregulated in SD group as shown in the heat map (Figure 5(a)).
To achieve more discriminative power, a biomarker group was generated including 6 upregulated (creatine, tryptophan, N-acetylhistidine, L-carnitine, pyroglutamic acid, and indoleacrylic acid) and 10 downregulated (prolinebetaine, L-acetylcarnitine, pipecolic acid, xanthurenic acid, trigonelline, kynurenic acid, indole-3-carboxylic acid, phosphorylcholine, 4-pyridoxic acid, and thymine) metabolites with AUC > 0.85.
Reference Methods Sample [36] UPLC- LTQOrbitrap-MS Serum [37] RP-HPLC-QTOF-MS and HILIC-QTOF-MS Serum [38] GC/MS Serum [39] 1 H-NMR Serum Reference Main findings [36] The nine metabolites differentiated A- grade from the control group, including nicotinamide, aminoadipic acid, glutamine, tyramine, dodecenoic acid, lysophosphatidylcholine, glycol-cysteine, cysteine amino acid, and octenoic acid; three metabolites that distinguished grade A from B, including ethanolamine, glycine, glycosylchenodeoxycholic acid; 10 metabolites that differentiated grade B from C, including aminoadipic acid, taurine, aminoacetone, glycine, pyruvate, glycolcholodeoxycholic acid, alanine, pipecolic acid, methionine, and serine.
6Pyridoxine dependency was suspected clinically as the patient had intractable seizures but patient did not survive long enough to undergo further work up including CSF Pipecolic acid.
In addition, the roles of other metabolites identified in this research, for example, benzoic acid, L-aspartyl-L-phenylalanine, pipecolic acid, pyroglutamic acid, N-phenylacetamide, phenylpyruvate, and aminobutyric acids, which were all increased as the result of BSP consumption are not understood at this time and, thus, requires further studies to elucidate the underlying mechanism.
Pipecolic acid, also known as homoproline or piperidine-2-carboxylic acid, a six-carbon natural nonproteinogenic [alpha]-amino acid, is an intermediate of lysine metabolism in various organisms including bacteria, yeast, fungi, and mammals.
Lysine metabolism in the rat brain: Blood-brain-barrier transport, Formation of pipecolic acid and human hyperpipecolatemia.
Plasma levels of pipecolic acid, both L- and D-enantiomers, in patients with chronic liver diseases, especially hepatic encephalopathy.
[3] Nonstandard abbreviations: 4-NA, 4-nitroanilide; [[alpha].sub.2]-M, [[alpha].sub.2]-macroglobulin; Pip, pipecolic acid; Sar, sarcosine (N-methyl glycine); CBZ, carbobenzoxy; PEG, polyethylene glycol; and mPEG, methoxypolyethylene glycol.
2) is characterized by the presence of quasimolecular ions of mass m/z = 922 [(MNa).sup.+] and 938 [(MK).sup.+] and by fragmentation ions of mass m/z = 906 (M - C[H.sub.3]OH)[K.sup.+], 890 (M - C[H.sub.3]OH)[Na.sup.+], 785 (M - 115)[H.sup.+], 769 (M - C[H.sub.4] - 115)[H.sup.+], 755 (M - 3[H.sub.2]O -- pipecolic acid)[K.sup.+], and 737 (769 - C[H.sub.3]OH)[H.sup.+], proving that a demethylation process occurred under the influence of the cytochrome P-450-dependent mixed-function oxygenase system as illustrated in the fragmentation pathway of Fig.