pioglitazone


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pioglitazone

 [pi″o-glit´ah-zōn]
an agent used in treatment of type 2 diabetes mellitis, decreasing insulin resistance in the peripheral tissues and liver, used orally as the hydrochloride salt.

pioglitazone

/pi·o·glit·a·zone/ (pi″o-glit´ah-zōn) an antidiabetic agent that decreases insulin resistance in the peripheral tissues and liver; used as the hydrochloride salt in the treatment of type 2 diabetes mellitus.

pioglitazone

(pī′ō-glĭt′ə-zōn′)
n.
A thiazolidinedione drug, C19H20N2O3S, used in its hydrochloride form to treat type 2 diabetes.

pioglitazone

an oral antidiabetic.
indication It is used to treat stable type 2 diabetes mellitus.
contraindications Lactation, diabetic ketoacidosis, and known hypersensitivity to this drug prohibit its use. It is also contraindicated in children.
adverse effects Common adverse effects include myalgia, sinusitis, upper respiratory infection, pharyngitis, headache, and aggravated diabetes mellitus.

pioglitazone

Actos® Endocrinology An oral antidiabetic that ↓ insulin resistance, used to manage type 2 DM; it inhibits hepatic gluconeogenesis, and improves glycemic control while ↓ circulating insulin Adverse effects Edema, ↑ URIs, headaches, myalgias, sinusitis. See Diabetes mellitus.
References in periodicals archive ?
OSAKA, Japan, July 30, 2015 /PRNewswire/ -- Takeda Pharmaceutical Company Limited ("Takeda") today announced the completion of the study to fulfill the post-marketing commitment and submissions of data to regulatory authorities from the Pan European Multi-Database Bladder Cancer Risk Characterization Study, a large (n= 112,674), multi-database retrospective matched cohort study, conducted in four European countries, for pioglitazone containing medicines, including ACTOS (pioglitazone HCI) with up to 10 years of follow-up.
Rosiglitazone use was curbed due to heart concerns, although restrictions were later lifted, while pioglitazone was hit by concerns over a possible link to bladder cancer.
In the phase III, randomized, placebo-controlled, double-blind PIVENS trial, vitamin E therapy was compared to pioglitazone and placebo in 247 nondiabetic adults (N.
Pioglitazone is indicated as second or third line treatment of type 2 diabetes as monotherapy and dual oral therapy.
Pioglitazone hydrochloride was obtained as a gift sample (Cipla Pharmaceuticals Ltd, India).
8 percent, similar to those on linagliptin plus pioglitazone (76 percent).
During the study, scientists conducted some tests on type 2 diabetes patients, who consumed pioglitazone and they were compared with patients who consumed rosiglitazone, another type 2 diabetes drug.
But like several other hypoglycemic agents; pioglitazone therapy also causes weight gain.
Based on their knowledge that NASH arises from persistent insulin resistance and oxidative stress, they examined the effects of pioglitazone (Actos[R]), an insulin-sensitizing drug, and vitamin E.
Our study shows that increased fracture risk is associated with higher TZD dose, but no difference between rosiglitazone and pioglitazone is apparent, suggesting a class effect of TZDs on fracture risk," senior author William Herman, also of the university, said in a prepared statement.
The drugs rosilglitazone and pioglitazone are being compared at 10 sites in India -- Bangalore, Karnal, Kottayam, Vijaywada, Mumbai, Nasik, Pune, Trichy, and two sites in Kochi -- to see if rosiglitazone is associated with more risk for patients.