There is evidence that adrenalectomy in rats lead to significant increase in number of pinealocyte
processes and increase in melatonin forming enzyme hydroxy indoleomethyl transferase (HIOMT) which ultimately leads to an increase in pineal endocrine activity (Deuben-Schmitter et al.
Biosynthesis of melatonin in pinealocytes
is a multistep sequence of reactions that starts with the hydroxylation of the amino acid tryptophan to 5-hydroxytryptophan (5-HTP) by the tryptophan hydroxylase (TPH).
An example of rat pineal gland and pinealocytes
(based on Ferreira-Medeiros et al.
The pineal gland is an endocrine gland of epithelial origin, as the CNS, formed by pinealocytes
(modified neurons), astrocytes, and microglia .
Effect of superior cervical ganglionectomy on the ultrastructure of pinealocytes
in the Djungarian hamster (Phodopus sungorus): Quantitative study.
Two cells of interest in the brain-gut axis are pinealocytes
and enterochromaffin cells.
5 G, 60 Hz magnetic field suppresses melatonin production in pinealocytes
D-Aspartate modulates melatonin synthesis in rat pinealocytes
It consists of pinealocytes
surrounded by connective tissue.
The results from this study suggest that the pinealocytes
may be as susceptible to fluoride as the developing enamel or-gan.
The age-related quantitative ultrastructural changes in pinealocytes
Direct exposed to a source of white light during incubation also may cause a number of teratological effects in chickens such as higher mortality, lower eye weight, and the increase in number and size of the intracytoplasmic lipid droplets of the follicular pinealocytes
(Aige-Gil and Murillo-Ferrol, 1992; Archer et al.