To do this, cell apoptosis, the expression of TH(+) fibers, Bax, and Bcl-2, and the MDA content were analyzed, following a pinealectomy
(PX) and MT replacement therapy.
Other studies have reported neuroprotective effect of melatonin in different animal models, including irradiation, aging, spinal cord injury, ischemia, hypoxia, and pinealectomy
prevents the nocturnal decrease in plasma glucose concentration which results in an increased 24-hour mean glucose concentration in rats.
was achieved using propranolol followed by exogenous hydrocortisone treatment.
Among these factors, constant illumination, sound, steroid hormones use in newly born, ionizing radiation exposition and pinealectomy
aggravates and melatonin administration attenuates brain damage in focal ischemia.
In animal studies as far back as 1964, melatonin injections in mice demonstrated a core temperature drop of 2-3[degrees]C (Arutyanyan, Mashkowski, & Roshchina, 1964), whereas pinealectomy
in sheep and rabbits resulted in increased body temperatures (Dawson & van den Heuvel).
Geographic differences for delay of sexual maturation in Peromyscus leukopus: effects of photoperiod, pinealectomy
, and melatonin.
Effects of photoperiod, melatonin and pinealectomy
on ethanol consumption in rats.
or superior cervical ganglionectomy do no alter reproduction in the wolf (Canis lupus).
Methods: One hundred and twenty normal male Wistar rats were randomly divided into the control, sham operation pinealectomy
(PX), sham operation gonadectomy (GDX), PX, GDX, and PX + GDX groups.
After the demonstration that the enzymes responsible for melatonin synthesis are present in the gastrointestinal tract and that the content of melatonin is maintained even after pinealectomy
, it was proposed that melatonin should have a local role, independent of darkness control.