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An antifungal antibiotic for topical use, produced by Streptomyces natalensis; effective against Aspergillus, Candida, and Mucor species.
Synonym(s): natamycin
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Bark pieces, about 2-4mm-wide, were cut from the edge of the lesions and placed on cornmeal agar (CMA) (Sigma-Aldrich Chemie GmbH, Germany) amended with 10mg pimaricin, 200mg ampicilin, 10mg rifampicin, 10mg benomyl, 25mg pentachloronitrobenzene and 50mg hymexazol (PARBPH) [8].
Amphotericin B, nystatin, and pimaricin are polyene antibiotics widely used clinically because of their high affinity for ergosterol and relatively low affinity for its mammalian counterpart, thereby limiting their toxicity in mammalian cells (20).
Samples of roots from these grasses were rinsed thoroughly with water, surface sterilized with 50% ethyl alcohol, and then dried with sterile paper towels before being placed onto selective media (PARP - pentachloronitrobenzene ampicillin rifampicin pimaricin medium) (Jeffers and Martin 1986).
Infected tissues of previously collected leaves were placed in petri-dishes containing rye agar medium supplied with antibiotic 100 L/mL vancomycin 100 L/mL pimaricin and 50 L/mL rifamycin (Caten and Jinks 1968).