Factors are based on the surface area and distribution/density of
pilosebaceous units.
This review article summarizes up-to-date knowledge and hypotheses of PCA, especially in pathogenesis and treatment, focusing on one of the latest ideas: peroxisome proliferator-activated receptor [gamma] (PPAR-[gamma]) involvement in lipid homeostasis within
pilosebaceous units.
acnes is part of the skin and mucous membrane commensal microbial flora [8] and is mainly located in the
pilosebaceous follicles and external auditory canal.
However, this study considered [alpha]-synuclein inclusions in the epidermis and in
pilosebaceous units but did not specifically assess intraneural accumulation [12].
In this type of burn, the
pilosebaceous complexes situated in the lower area of the deep reticular dermis remain intact.
Histopathological examination revealed a cyst lined by keratinizing squamous epithelium with attached
pilosebaceous structures suggestive of dermoid cyst.
A skin biopsy taken from these nodules revealed the presence of multiple foamy macrophages surrounding
pilosebaceous units (Figure 5A).
Pores are actually the tiny openings of the
pilosebaceous and sweat ducts on the skin surface.
acnes resides in
pilosebaceous follicles of the skin, colonizing the lipid-rich sebaceous glands.
Preliminary animal studies suggest that minocycline delivered by the BPX-01 formulation is absorbed into the skin, reaching the epidermis and the
pilosebaceous region where acne develops.
Histopathology revealed a keratinizing squamous epithelium with
pilosebaceous structures in the cyst wall consistent with a dermoid cyst.
Acne vulgaris is a chronic inflammatory disease of the
pilosebaceous unit, characterized by seborrhea, formation of comedones, erythematous papules, and pustules and less frequently by nodules, deep pustules, or pseudocysts [1].
