pilocarpine


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pilocarpine

 [pi″lo-kahr´pin]
a cholinergic alkaloid from leaves of Pilocarpus jaborandi and P. microphyllus; used topically in the eye as the base or the hydrochloride or nitrate salt as an antiglaucoma agent and miotic; the hydrochloride salt is also used orally to treat mouth dryness resulting from radiotherapy or associated with Sjögren's syndrome. The nitrate salt has also been administered by iontophoresis to produce sweating in a test for cystic fibrosis.

pi·lo·car·pine

(pī'lō-kar'pēn),
An alkaloid obtained from the leaves of Pilocarpus microphyllus or P. jaborandi (family Rutaceae), shrubs of the West Indies and tropical America; a parasympathomimetic agent used experimentally to induce seizures externally as a miotic and in the treatment of glaucoma; used as the hydrochloride and the nitrate salts.
[G. pilos, a felt hat, + karpos, fruit]

pilocarpine

(pī′lō-kär′pēn′)
n.
A colorless or yellow poisonous compound, C11H16N2O2, obtained from the leaves of the jaborandi and used to induce sweating, promote salivation, and treat glaucoma.

pilocarpine

Therapeutics An alkaloid with mild β-adrenergic activity which, topically, ↓ intraocular pressure in glaucoma; it stimulates glands, resulting in diaphoresis, salivation, lacrimation it may be used to treat post-radiation or opioid-induced xerostomia, gastric and pancreatic secretion

pi·lo·car·pine

(pī'lō-kahr'pēn)
An alkaloid obtained from the leaves of Pilocarpus microphyllus or P. jaborandi, shrubs of the West Indies and tropical Americas; a parasympathomimetic agent used experimentally to induce seizures externally as a miotic and in the treatment of glaucoma.
[G. pilos, a felt hat, + karpos, fruit]

pilocarpine

A drug used in the form of eye-drops to treat GLAUCOMA. Pilocarpine causes extreme constriction of the pupils so that traction is exerted on the root of the iris so as to open up the drainage channels for aqueous humour. The drug is on the WHO official list. Brand names are Minims pilocarpine, Pilogel, Salagen, Sno Pilo, and, in the form of a sustained-release insert placed behind an eyelid and left for a week at a time, Ocusert Pilo.

pilocarpine 

An alkaloid obtained from the leaves of Pilocarpus microphyllus and other species of Pilocarpus. It is a parasympathomimetic (direct-acting cholinergic) drug, which mimics the effect of acetylcholine causing miosis and accommodation. It counteracts sympathomimetic mydriatics. It is used in the treatment of glaucoma. Pilocarpine hydrochloride is most commonly applied to the eye as a 1% solution. Carbachol and bethanechol chloride are other parasympathomimetic drugs with similar effects to pilocarpine. See parasympathomimetic drug; physostigmine.

pi·lo·car·pine

(pī'lō-kahr'pēn)
An alkaloid used experimentally to induce seizures externally as a miotic and to treat glaucoma.
[G. pilos, a felt hat, + karpos, fruit]
References in periodicals archive ?
Fifty-two patients taking timolol had treatment changed to pilocarpine or betaxolol and 20 controls continued to take timolol.
Cavalheiro, "Physical training reverts hippocampal electrophysiological changes in rats submitted to the pilocarpine model of epilepsy," Physiology and Behavior, vol.
As shown in Figure 2, the percentage of no induced seizures increased by 6.7% (a), the latency to generalized convulsion after pilocarpine administration was extended (b), and theseizure severitywas reduced (c) inthe APT group compared with the APE group.
Denervation hypersensitivity to dilute pilocarpine as a result of damage to the pupillary parasympathetic supply is known to occur in diabetic patients before the sympathetic pathway is affected.
Barbosa et al., "Effects of the vitamin E in catalase activities in hippocampus after status epilepticus induced by pilocarpine in Wistar rats," Neuroscience Letters, vol.
Pilocarpine (300mg/kg ip), preceded by methylscopolamine (l mg/kg, sc) and pentylenetetrazol (PTZ, 50 mg/kg ip) were used to induce seizures as described previously (Lian et al., 2005).
What is used under the negative electrode (not the positive pilocarpine electrode) during iontophoresis?
Saliva stimulation: Cholinergic drugs such as pilocarpine may be tried, unless medically contra-indicated (Table II).
A drug called pilocarpine hydrochloride has been shown to be safe and effective in relieving dry mouth, often associated with Sjogren's syndrome.
Tab Pilocarpine 5mg Cough Losenzes Tab Septilin etc.
A relatively slightly better IOP was controlled for patients taking timolol and pilocarpine compared to other medications (Figure 5).
Diagnosis is established with rapid miotic response of affected pupil to 0.125% pilocarpine drop.