Tesetaxel has several potential therapeutic advantages over currently available taxanes, including oral administration with a low pill burden
, a patient-friendly dosing regimen, and a formulation that does not contain solubilizing agents that are known to cause hypersensitivity (allergic) reactions.
Dr Haidry said: "The purpose is not to get someone off medication completely, but to reduce that pill burden
while eliminating the chance of it getting worse.
People living with HIV have always faced complex treatment regimens and a high pill burden
Figure 1 depicts the daily pill burden
for HD patients.
Also, if possible, consider comorbid disease states that allow for prescribing 1 medication that can treat 2 conditions to reduce pill burden
(eg, duloxetine for depression and diabetic neuropathy).
Patients on HD have multiple comorbidities and have the highest pill burden
of all chronically ill patient populations with an estimated daily average of 12 medications (Chiu et al.
AstraZeneca chief medical officer and global medicines development executive vice president, Sean Bohen, said, 'The tablet formulation may offer patients a reduced pill burden
for Lynparza and a safety profile that is generally consistent with previous trials.
In spite of those hurdles, according to PhRMA, the last decade has seen the introduction of treatments that offer diabetes patients better and more sustained blood glucose control, reduced pill burden
, less frequent injections and more convenient delivery mechanisms, all leading up to simpler daily routines that, in turn, make adherence easier.
Other regimens have limited supporting data, reduced virologic activity, a higher pill burden
, more drug interactions, and greater toxicity.
13) The possibility that the increased pill burden
(as in the case of switching from zidovudine + lamivudine coformulation to ABC/lamivudine as single components) might have contributed, at least in part, to the virologic failures observed in patients cannot be definitively ruled out.
Based on her experiential knowledge, Lucy feels that the overwhelming pill burden
, the interminably long duration of treatment, and the debilitating side effects, coupled with lack of proper counselling, often make the patients to not comply with treatment.
Most diabetic patients say their large pill burden
is an issue, and they think onychomycosis is the least important of their problems," she explained.