If approved, this new treatment option eliminates the need to take a boosting agent in a separate tablet with once-daily darunavir, reducing the pill burden
The treatment is a pure, free fatty acid form that can provide physicians with an alternative to efficiently direct the condition without dramatically increasing a patient s pill burden
, AstraZeneca further explained.
In patients receiving dialysis, higher pill burden
has been associated with reduced health-related quality of life (Chiu, Teitelbaum, Misra, de Leon, Adize, & Mehrotra, 2009).
9,10) All these data indicate that pharmacokinetic interactions, high pill burden
and potential intolerance of combined multi-drug regimens do not undermine ART outcomes to an appreciable extent.
She would need to know the major side effects of each of the medications as well as the pill burden
, food restrictions and fluid requirements.
However, phosphate binders Renagel (sevelamer hydrochloride), Renvela (sevelamer carbonate), Fosrenol (lanthanum carbonate) and Phoslo Gelcaps (calcium acetate) all show low patient compliance due to low efficacy and safety profiles, common side effects such as gastrointestinal intolerance, a high pill burden
, and a high expense of therapy.
The 2006 launch of Atripla, the first single-tablet regimen (STR) for the treatment of HIV infection, marked an important advancement in antiretroviral therapy (ART), significantly enhancing efficacy and reducing pill burden
Benefits include improved drug efficiency, reduced pill burden
, and lower dosage frequency
Because Parkinson's disease patients typically have to take many doses of medications each day, the re-approval of the patch will hopefully help a lot of sufferers," by cutting pill burden
, among other things, Dr.
This regimen would have a total pill burden
of 9 capsules twice a day.
Over 90% of patients with kidney failure use oral phosphate binders to prevent hyperphosphatemia, yet there is often poor compliance due to gastrointestinal (GI) intolerance and excessive pill burden
associated with current therapies.
With this approval we are providing an alternative solution and a reduced pill burden
which should make it easier for patients to manage their treatment on a day-by-day basis and keep their HIV at undetectable levels.