picrotoxin


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Related to picrotoxin: Bicuculline, CNQX

pic·ro·tox·in

(pik'rō-tok'sin),
A bitter neutral principle derived from the fruit of Anamirta cocculus (family Menispermaceae); a CNS stimulant; a convulsant and GABA antagonist used extensively in experimental procedures studying seizure mechanisms.
Synonym(s): cocculin
[G. pikros, bitter, + toxicon, poison]

picrotoxin

(pĭk′rə-tŏk′sĭn)
n.
A bitter crystalline compound, C30H34O13, derived from the seed of a tropical Asian woody vine (Anamirta cocculus) and used as a stimulant, especially in treating barbiturate poisoning.

picrotoxin

[pik′rōtok′sin]
Etymology: Gk, pikros, bitter, toxikon, poison
a central nervous system stimulant obtained from the seeds of Anamirta cocculus, formerly used as an antidote for acute barbiturate poisoning.

picrotoxin

a central nervous system and respiratory stimulant formerly used in barbiturate and other anesthetic poisonings; extracted from the seeds of the plant Anamirta cocculus.
References in periodicals archive ?
To ensure that picrotoxin itself did not present a stimulatory effect, silver catfish (n=4) were exposed to picrotoxin (100 mg/L) or water for 30 min.
The positive control group: mice received the amount of 40 ml/kg phenobarbital 20 min before picrotoxin injection.
Picrotoxin (10mg/kg) was administered after 60 minutes of simvastatin application in the last three groups.
The effect of L-arginine on the memory impairing action of phenobarbitone in rats that convulsed after the injection of picrotoxin.
A single amino acid in [gamma]-aminobutyric acid p1 receptors affects competitive and noncompetitive components of picrotoxin inhibition.
L-PA increased sleeping posture and decreased waking posture, and the GABA-A antagonist picrotoxin attenuated the effects.
Furthermore, the reduction of cSNC by ethanol treatment can be reversed by the coadministration of drugs that interfere with the a-aminobutyric acid (GABA) receptor, including the GABA antagonist picrotoxin (Becker & Anton, 1990), and the partial inverse agonist Ro 15-4513 (Becker & Hale, 1991).
Picrotoxin in the medial prefrontal cortex impairs sensorimotor gating in rats: Reversal by haloperidol.
An odorless, tasteless, and water-soluble white crystalline powder that acts as a [gamma]-amino butyric acid (GABA) antagonist (China Center for Disease Control and Prevention [CDC], unpublished data, 2002), TETS, like picrotoxin, binds noncompetitively and irreversibly to the GABA receptor on the neuronal cell membrane and blocks chloride channels.
Nonspecific binding was determined in parallel incubates including additional unlabeled picrotoxin.
picrotoxin, used worldwide as a nervous system stimulant from Anamirta sp.
Administration of a drug called picrotoxin breaks down these rhythmic pulses in bee brains, the investigators report.