picrotoxin


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Related to picrotoxin: Bicuculline, CNQX

pic·ro·tox·in

(pik'rō-tok'sin),
A bitter neutral principle derived from the fruit of Anamirta cocculus (family Menispermaceae); a CNS stimulant; a convulsant and GABA antagonist used extensively in experimental procedures studying seizure mechanisms.
Synonym(s): cocculin
[G. pikros, bitter, + toxicon, poison]

picrotoxin

(pĭk′rə-tŏk′sĭn)
n.
A bitter crystalline compound, C30H34O13, derived from the seed of a tropical Asian woody vine (Anamirta cocculus) and used as a stimulant, especially in treating barbiturate poisoning.
References in periodicals archive ?
Rapid IPSPs produced by CBI-3 in the egestive buccal interneuron B20 (see Colocalization of GABA and Dopamine) were blocked by picrotoxin and bicuculline (Jing et al., 2003).
For the two lowest concentrations of picrotoxin (Sigma) used here (0.1 and 1 [micro]M), 10x stock solutions were prepared (1 and 10 [micro]M, resp.) and diluted to the appropriate concentration on the day of the experiment.
To ensure that picrotoxin itself did not present a stimulatory effect, silver catfish (n=4) were exposed to picrotoxin (100 mg/L) or water for 30 min.
(E, F) Effects of a GABA antagonist, picrotoxin, (PTX, 100[micro]M).
The positive control group: mice received the amount of 40 ml/kg phenobarbital 20 min before picrotoxin injection.
Whole-Cell and Perforated-patch recordings: Whole cell recordings made using ASCF and [K.sup.+]-gluconate Ih recorded from layer II stellate neurons of the EC using the above extracellular solution, excluding picrotoxin and including Tetradotoxin (0.5 [micro]M).
Coexistence in DUM neurons of two GluCl channels that differ in their picrotoxin sensitivity.
(C) Cytoplasmic end of the transmembrane channel for two [beta]-3 subunits, indicated by closed circles in (6) in GAB[A.sub.A]R, showing the residues that form the binding site for picrotoxin (PTX) and RDX [closed circles in (C): residues numbered 1'-23' from the N-terminal bottom; open circles represent residues that are not part of the binding site].
Keywords: Seizures, Simavastain, Picrotoxin. (JPMA 62: 1187; 2012).
Ares-Pena, "An experimental set-up for measurement of the power absorbed from 900 MHz GSM standing waves by small animals, illustrated by application to picrotoxin treated rats," Progress In Electromagnetics Research, Vol.
Convulsion disorder induced experimentally by picrotoxin (PCT) has been found to impair the ability of rats to learn and to remember shock-avoidance task (28).
Professor Saleh said they injected a group of mice with strychnine and picrotoxin, two drugs which cause convulsions leading to death, while they fed another group of mice with a fluid made of foul before giving them the two drugs.