The panel agreed that pleconaril, administered at a dose of 400 mg three times a day for 5 days, was shown to be effective in the two studies, although the effect was modest: The time it took for symptoms to resolve was a median of a half day faster among all subjects who received pleconaril and a median of 1 day faster among those on pleconaril who were positive for picornavirus
at baseline, using a polymerase chain reaction assay.
Hepatitis A, caused by a picornavirus
, accounts for up to 35% of all cases of acute viral hepatitis in developed countries.
became the first to chart in atomic detail the topography of an animal virus -- human rhinovirus-14, a picornavirus
that causes colds.
Polio is caused by poliovirus, a member of the picornavirus
1] National Primary Health Care Development Agency, Nigeria;  Bill & Melinda Gates Foundation, Seattle, Washington;  Global Immunization Division, CDC;  United Nations Children's Fund, Nigeria Office;  CORE Group Partners Project, Nigeria;  Division of Virology, College of Medicine, University of Ibadan, Nigeria;  Polio And Picornavirus
Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, CDC.
The genus Enterovirus (EV), one group of the picornavirus
family, has the following species according to the International Committee on Taxonomy of Viruses: EV-A, which contains EV71 and several Coxsackievirus group A (CVA) viruses; EV-B (Coxsackievirus group B (CVB) viruses, CVA9, echoviruses and few other EV); EV-C (polioviruses (PV) 1-3, several CVA and few other EV); EV-D (EV-D68, EV-D111, EV 70 and EV74); EV-E, EV-F, EV-G, EV-H, EV-J, and the rhinoviruses (HRV-A, HRV-B, HRV-C).
We will use cryo-electron microscopy to study picornavirus
replication complexes in order to explain the mechanism of copy-choice recombination of picornavirus
RNA genomes that leads to creation of new picornavirus
It is evident that the antiviral mechanism of raoulic acid must be fully understood in order to develop a novel drug for the treatment of picornavirus
Of these, 11 were picornavirus
and 1 was influenza B.
Evidence of harm to the brain emerged from a study of mice which, when infected with a polio-like picornavirus
, had difficulty navigating a maze.
Rhinovirus 8 (35) 5 (20) Enterovirus 3 (13) 1 (4) Untypeable picornavirus
2 (9) 4 (16) Influenza A 1 (4) Adeno 4 (16) Parainfluenza type 1 1 (4) Parainfluenza type 3 1 (4) 1 (4) Respiratory syncytial virus 3 (13) 2 viruses 1 (4) 1 (4) Any of the above([dagger]) 16 (70) 16 (64) Pathogenic bacteria in nasopharynx Mycoplasma pneumoniae 1 (4) 1 (4) Streptococcus pneumoniae 2 (8) Haemophilus influenzae 1 (4) 3 (12) Moraxella catarrhalis 1 (4) 5 (20) Streptococcus pneumoniae Haemophilus influenzae, or Moraxella catarrhalis 2 (9) 10 (40) ([double dagger])
Concomitant meningoencephalitis has been reported in several cases, possibly reflecting the fact that HAV is a picornavirus
and thus relatively closely related to the enteroviruses, common causes of viral meningitis and meningoencephalitis in humans.