is found in low quantities in ruminant adipose and dairy formed through the metabolism of phytol following release from chlorophyll (Hellgren 2010).
In the conventional analysis of plasma phytanic acid, all lipids were first extracted in chloroform-methanol (1:1 by volume).
For patients with Refsum disease, phytanic acid [alpha]-oxidation can not take place because of a defect in the enzyme phytanoyl-CoA hydroxylase (EC 1.
Assignment of the methyl resonances is given in the spectrum of pure phytanic acid (Fig.
DEX, a glucocorticoid; MED, a progestin; PHY, a precursor to phytanic acid, an RXR and PPAR[alpha] activator; and DBP, a weak estrogen and antiandrogen, did not significantly alter uterine weights (Figure 1).
PHY, the precursor to the PPAR and RXR agonist phytanic acid, had no effects on any of the parameters examined, despite several studies that have demonstrated the binding of RXR (Joyeux et al.
Phytanic acid activates the peroxisome proliferator-activated receptor [alpha] (PPAR[alpha]) in sterol carrier protein 2-/sterol carrier protein x-deficient mice.
However, very little was known about the precise mechanism of the conversion of phytol to phytanic acid until our discovery of the involvement of FALDH in this pathway.
Identification of fatty aldehyde dehydrogenase in the breakdown of phytol to phytanic acid.
Phytanic acid a-oxidation, new insights into an old problem: a review.
From a diagnostic standpoint, the measurement of PA is considered as a supplementary test for peroxisomal diseases following the analysis of plasma very long chain fatty acids (VLCFAs), bile acids, phytanic acid, and pristanic acid.
Rapid stable isotope dilution analysis of very-long-chain fatty acids, pristanic acid and phytanic acid using gas chromatography-electron impact mass spectrometry.