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used by conjunctival instillation to reduce tension in glaucoma, in the treatment of postoperative intestinal atony and urinary retention, in the management of myasthenia gravis, and to counteract excessive doses of tubocurarine; also available as physostigmine sulfate, with the same uses.
Synonym(s): eserine salicylate
an acetylcholinesterase inhibitor.
indications It is an ophthalmic preparation prescribed as a miotic agent for the treatment of glaucoma, and it is administered systemically for treating the toxic effects of excessive cholinergic receptors blockade (e.g., resulting from atropine poisoning).
contraindications Asthma, gangrene, diabetes, cardiovascular disease, or mechanical obstruction of the intestines or urinary tract prohibits its use. It is also not administered to patients in any vagotonic state or to those receiving choline esters or depolarizing neuromuscular blocking agents.
adverse effects Among the adverse effects are hypersalivation, diaphoresis, lacrimation, miosis, bradycardia, palpitations, nervousness, and convulsions.