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a cholinergic alkaloid having anticholinesterase activity, obtained from the dried ripe seed (Calabar bean) of Physostigma venenosum; used topically to produce miosis and to decrease intraocular pressure in glaucoma. It may also be applied parenterally to reverse the central nervous system effects produced by overdosage of anticholinergic drugs.
An alkaloid of physostigma; it is a reversible inhibitor of the cholinesterases and prevents destruction of acetylcholine; used as a cholinergic agent, and experimentally to enhance the action of acetylcholine at any of its sites of liberation.
physostigmine/phy·so·stig·mine/ (-stig´mēn) a cholinergic alkaloid usually obtained from dried ripe seed of Physostigma venenosum (Calabar bean), used as a topical miotic and to reverse the central nervous system effects of an overdosage of anticholinergic drugs; used in the form of the salicylate and sulfate salts.
A crystalline alkaloid, C15H21N3O2, extracted from the Calabar bean, used in the form of its sulfate as a miotic and in the form of its salicylate as a cholinergic agent. Also called eserine.
physostigmineA reversible antiacetylcholinesterase, used in Pts with Sx of an anticholinergic crisis Neurology Memory drug Physostigmine may improve working memory by ↑ efficiency and ↓ effort. See Working memory.
A nonpolar carbamate antidote to anticholinergic compounds.
physostigmineA CHOLINESTERASE inhibitor drug used to constrict the pupil of the eye and lower the pressure within the eye in GLAUCOMA. It is also used to treat poisoning with ANTICHOLINERGIC drugs. It is derived form the Calabar bean Physostigma venenosum . Also known as eserine.
A reversible anticholinesterase drug used as a parasympathomimetic which, when used in the eye constricts the pupil. It may be used in solution of 0.25-1% or ointment 0.25-0.50% in the treatment of glaucoma, but because of its side-effects its usage is rare nowadays. It is sometimes combined with pilocarpine. Syn. eserine. See miotics; neostigmine; parasympathomimetic drug.
Alkaloid used as a cholinergic agent, and experimentally to enhance action of acetylcholine at any of its sites of liberation.
an alkaloid usually obtained from the dried ripe seed of Physostigma venenosum; used as a topical miotic in the form of the base and of the salicylate and sulfate salts.
physostigmine challenge test
a test for the diagnosis of cataplexy; after increasing doses of physostigmine, affected dogs show a dose-related severity of reactions when offered food.