physiologically based pharmacokinetic modeling


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physiologically based pharmacokinetic modeling

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PBPK

A means of assessing the behavior of various chemical compounds in living organisms based upon their apparent absorption, distribution, and elimination from the body, and such in vitro characteristics as their plasma protein binding and cell membrane permeability. PBPK mathematical modeling is used in pharmacology to select promising new agents for therapeutic use, and in toxicology to estimate the potential harm that chemicals may cause when ingested by animals or released into the environment.
References in periodicals archive ?
Physiologically based pharmacokinetic modeling of arterial-antecubital vein concentration difference.
Physiologically based pharmacokinetic modeling with methylchloroform: implications for interspecies, high dose/low dose, and dose route extrapolations.
The application of physiologically based pharmacokinetic modeling in human health risk assessment of hazardous substances.