9) The hallmark cell of chordoma is the large physaliphorous cell
with a central nucleus and numerous clear cytoplasmic vacuoles.
Histological examination revealed scattered physaliphorous cell
nests with a lobular growth pattern.
Histopathologically, a chordoma is characterized by the presence of its hallmark physaliphorous cell
, embedded in myxoid to chondromyxoid matrix.
Microscopically, chordomas consist of nests or cords of physaliphorous cells
separated by fibrous tissue septa and mucoid intercellular substance.
Microscopic examination revealed myxoid matrix with round cells with occasionally larger cell containing multivacuaolated cobweb-like cytoplasm, so called physaliphorous cells
and the patient is subjected to radiotherapy.
Myxoid variant of chordoma is differentiated by its location in the sacrococcygeal region, base of skull, or the cervical spine and the presence of multinucleated, physaliphorous cells
The epithelioid cells are slightly elongated, with associated large mucus-containing physaliphorous cells
Many of the tumour cells exhibit vacuolization of the cytoplasm resembling physaliphorous cells
Both notochordal vestiges and EPs show the characteristic physaliphorous cells
and demonstrate similar immunohistochemical staining pattern.
were noted (figure 2), which stained strongly for S-100, epithelial membrane antigen (EMA) and, focally, AE1-3 cytokeratin.
On microscopy, smears were cellular comprising of round to pleomorphic cells arranged in clusters, monolayered sheet and scattered singly and classic mono and bi nucleated physaliphorous cells
Histologically, chordoma is composed of 2 cell populations, multivacuolated physaliphorous cells
(Figure 9, A) and pink epithelioid cells (Figure 9, B), arranged in anastomosing cords in a myxoid or occasionally cartilaginous matrix, the latter typically seen in chondroid chordomas occurring predominantly in the skull base.