(9) The hallmark cell of chordoma is the large physaliphorous cell
with a central nucleus and numerous clear cytoplasmic vacuoles.
Histological examination revealed scattered physaliphorous cell
nests with a lobular growth pattern.
Histopathologically, a chordoma is characterized by the presence of its hallmark physaliphorous cell
, embedded in myxoid to chondromyxoid matrix.
Histologically, they both show the characteristic physaliphorous cell
; they stain for vimentin, S100, epithelial membrane antigen, and low molecular weight cytokeratins; and they are negative for high molecular weight keratins.
(a) Hematoxylin and eosin stain showing pathognomonic physaliphorous cells
with multivacuolated cytoplasm.
Histologically, the lesion was mainly composed of extremely large cells (known as physaliphorous cells
), with vacuolated PAS positive cytoplasm and prominent vesicular nuclei with mild atypia, combined to small tumor cells with inconspicuous and no visible nuclei.
Microscopically, chordomas consist of nests or cords of physaliphorous cells
separated by fibrous tissue septa and mucoid intercellular substance.
Microscopic examination revealed myxoid matrix with round cells with occasionally larger cell containing multivacuaolated cobweb-like cytoplasm, so called physaliphorous cells
and the patient is subjected to radiotherapy.
Myxoid variant of chordoma is differentiated by its location in the sacrococcygeal region, base of skull, or the cervical spine and the presence of multinucleated, physaliphorous cells
. Myxoma is less cellular, having cytologically bland cells that are separated by abundant myxoid stroma and show a dearth of vascular structures.
The epithelioid cells are slightly elongated, with associated large mucus-containing physaliphorous cells
Many of the tumour cells exhibit vacuolization of the cytoplasm resembling physaliphorous cells
. Significant areas of cartilaginous differentiation are also identified.
were noted (figure 2), which stained strongly for S-100, epithelial membrane antigen (EMA) and, focally, AE1-3 cytokeratin.