In our series both the benign phyllodes
and the giant fibroadenoma showed an adolescent age distribution range of 12-20 years.
Preoperative open biopsy was taken which revealed benign phyllodes
tumor on histopathology.
Significant histologic features differentiating cellular fibroadenoma from phyllodes
tumor on core needle biopsy specimens.
of the breast may occur in women of any age group from puberty to menopause. Its early clinical manifestations were painless, with presentation of solitary masses mostly in the left breast and commonly in the upper outer quadrant of the breast.
(32) Key histologic features that aid in the differential diagnosis are the characteristic leaflike fronds with stromal expansion and benign epithelial lining of phyllodes
tumor (Figure 2, A).
(%) Head and neck 11 (15) Intra-abdomen 30 (40) Retroperitoneum 15 (20) Lung 35 (47) Liver 22 (29) Bone 18 (24) Lymph node 16 (21) Others 29 (39) Maximum length Median (cm) 5.3 (0-21.7) >5 cm 40 (53) Pretreatment Operation 49 (65) Radiation 21 (28) Chemotherapy 8 (11) None 18 (24) Histopathology type Leiomyosarcoma 17 (23) Liposarcoma 15 (20) Spindle cell sarcoma, NOS 14 (19) Pleomorphic sarcoma 6 (8) Synovial sarcoma 5 (7) Others * 18 (24) * Others include angiosarcoma, undifferentiated pleomorphic sarcoma, solitary fibrous tumor, low-grade fibromyxoid sarcoma, malignant peripheral nerve sheath tumor, breast phyllodes
tumor, round cell sarcoma with CIC rearrangement, neuroblastoma, malignant extrarenal rhabdoid tumor, and myxofibrosarcoma.
Leaf-like morphology, Positive/Negative: marked stromal CD34 Negative: CKs cellularity and nuclear pleomorphism.
(5) The histogenesis of primary osteosarcoma of the breast has not been fully elucidated, though an origin from totipotent mesenchymal cells of the breast stroma or a transformation from a pre-existing fibroadenoma or phyllodes
tumor have been suggested.
These rare breast lesions are fibromatosis, idiopathic granulomatous mastitis, tubular adenoma, diabetic mastopathy, invasive micropapillary carcinoma, osteoclastic giant cell breast carcinoma, malignant phyllodes
tumor, carcinoma arising in fibroadenoma, metastasis, and metaplastic carcinoma.
The carcinogenetic pathway of primary osteosarcoma is poorly understood, but the leading hypotheses are that they either arise from totipotent mesenchymal cells in the breast stroma or from transformation of preexisting phyllodes
tumors or fibroadenomas [3, 4].
The differential diagnosis of JHB includes giant fibroadenomas, phyllodes
tumour, and malignant tumour such as lymphoma and sarcomas.
Cattelani, "Nipple sparing mastectomy with immediate silicone implant reconstruction for malignant phyllodes
tumor in a 19-year-old girl," European Review for Medical and Pharmacological Sciences, vol.